Lecture 3 Part 2 Flashcards
Fluid outside cells
Interstitial fluid
Interstitial fluid is made of:
Amino acids Sugars Fatty acids Vitamins Hormones Salts Wastes
Plasma membrane only allows some substances to enter cell
Selective Permeability
Two types of transport:
Passive
Actives
No energy (ATP) needed
Passive transport
Molecules move from high to low concentration
Down concentration gradient
Two types of passive transport:
Diffusion
Filtration
Nonpolar and lipid-soluble substances diffuse directly through lipid bilayer
Simple diffusion
Example of substances that undergo simple diffusion
O2
CO2
Fat-soluble vitamins
Transport proteins (carrier or channel proteins) assist molecules across membrane
Facilitated diffusion
Example of transport proteins:
Glucose
Amino acids
H2O
Ions
Water-filled channels
Channel proteins
Example of channel proteins:
Ions
Binds molecule, changes shape, ferries it across membrane
Carrier proteins
Example of carrier proteins:
Glucose transporter
Diffusion of H2O
Osmosis
Channel proteins for H2O passage
Aquaporins
Ability of solution to change shape or tone of cells by changing water volume
Tonicity
Types of tonicity:
Isotonic
Hypertonic
Hypotonic
Equal concentration solutes
Isotonic
Higher concentration of solutes
Hypertonic
Lower concentration of solutes
Hypotonic
Energy (ATP) is needed
Active transport
Molecules move from low to high concentration
Against concentration gradient
Types of active transport:
Primary
Secondary
Directly uses ATP to drive transport
Primary active transport
Example of primary active transport
Ca2+ pump
H+ pump
Na+ - K+ pump
Move more than 1 substance at a time
Secondary active transport
2 substances moved in same direction
Symport
2 substances cross in opposit direction
Antiport
Examples of secondary active transport:
Cotransport of sugars, amino acids, and ions
Fluid and large particles transported across membranes in vesicles (sacs)
Vesicular transport
“Out of cell” - eject substances
Exocytosis
“Within the cell” - ingest substances
Endocytosis
Types of endocytosis:
Phagocytosis
Pinocytosis
Receptor-mediated endocytosis
Cell eating - engulf large or solid material
Phagocytosis
Example of phagocytosis:
WBC engulf bacteria
Cell drinking - fluid with dissolved molecules
Pinocytosis
Example of pinocytosis:
Intestinal cells
Concentrate specific substances (ligands) that bind to receptor proteins
Receptor-mediated endocytosis
Examples of receptor proteins:
Insulin
Iron
Cholesterol