Lecture 8 Flashcards
Initial response of the body to injury
Inflammation
Accidental cell death
Causes inflammation
Necrosis
Programmed cell death
Normal step-by-step process that destroys cells no longer needed by the body
Apoptosis
Resolves over time by the healing of tissue
Acute inflammation
If inflammation persists, it becomes
Chronic
Diseased conditions
Examples of chronic inflammation
Arthritis
Tuberculosis
Four cardinal signs of inflammation
Redness
Seelling
Pain
Local Heat
Credited with documenting these signs during the days of the Roman Empire as early as the first century AD
Cornelius Celsus
Fifth sign that may also accompany inflammation
Loss of function
Reduce pain because they inhibit the synthesis of prostaglandins
Non-steroidal anti-inflammatory drugs (NSAIDs)
Decrease allergies by blocking histamine receptors and as a result the histamine response
Antihistamines
Tissue Repair phase
Removal of toxins Clotting (coagulation) Scab forms when clot dries Replacement of collagen Angiogenesis Vascularization Tissue repair
Describes the healing of a wound where the edges are close together
Primary Union
Occurs when there is a gaping wound, it takes longer to refill the area with cells and collagen
Secondary Union
Process in which the edges of the wound are pulled together
Wound Contraction