Lecture 8 9/12/23 Flashcards
What receptors are expressed on the surface of helper T cells?
-alpha/beta T cell receptor
-CD4
-CD3
-CD28
-PRRs
What is the role of CD4, CD3, and CD28?
they are important for activation and regulation of the T cell
What is the order in which the main signals for a T cell occur?
-TCR/antigen
-CD4
-CD28
Why are multiple receptors needed on a T cell?
to ensure the cell is only activated when there is a pathogen present, and is not activated in response to host
What are the three types of helper T cells?
-Th1
-Th2
-Th17
Which type of immunity is Th1 cells responsible for?
viral immunity/intra-cellular pathogen immunity
What is unique about viruses as a pathogen?
they are able to evade phagocytosis and replicate within phagocytic cells in addition to regular host cells
Which cytokine is produced by activated Th1 cells?
interferon-gamma
What is the role of interferon-gamma?
stimulates cytotoxic T cells to kill virus-infected cells
Which type of immunity is Th2 cells responsible for?
extra-cellular pathogen immunity (extra-cellular bacteria)
Which cytokines are produced by activated Th2 cells?
-IL-4
-IL-5
-IL-13
What are the roles of IL-4, IL-5, and IL-13?
-activate B cells to differentiate into plasma cells
-promote antibody production
How do antibodies influence the immune response?
they neutralize bacteria and their products
Which type of immunity is Th17 cells responsible for?
extra-cellular fungal (and some bacterial) immunity
Which cytokines are produced by activated Th17 cells?
-IL-17A
-IL-22
