Lecture 7 9/11/23 Flashcards
What are lymphocytes?
the cells responsible for adaptive immune responses
What are the two major types of lymphocyte?
-T cells involved in cell-mediated responses
-B cells involved in antibody production
Where are lymphocytes found?
-bone marrow
-lymph nodes
-spleen
-GI tract
-lymphatic fluid
-blood
What is the most important characteristic of lymphocytes microscopically?
different populations cannot be differentiated by shape, size, or morphology
What are the specific lymphocyte receptors found on lymphoyctes?
BCR on B cells
-TCR on T cells
What is cluster of differentiation desgination?
a classification of lymphocytes based on the surface molecules/receptors present
How are lymphocytes identified and differentiated?
flow cytometry
How are lymphocytes separated using flow cytometry?
-based on unique marker profiles
-specific surface markers are targeted with dyes/fluorescent antibodies or magnets
In addition to CD, what other molecular classification is seen in domestic animals?
workshop cluster, or WC
What are antigens?
foreign macromolecules that have been processed by cells for presentation to and recognition by BCRs and TCRs
What are the types of bacterial antigens?
-capsule/K
-pili/F
-flagellum/H
-cell wall/O
-toxins
What are the types of viral antigens?
-capsid protein layer coating
-surface proteins
Which molecules have the potential to act as antigens in infectious organisms?
-proteins
-carbohydrates
-lipids
-nucleic acids
How do pathogens evade antigen detection?
they mutate and evolve new antigens that the immune system has not seen before in order to evade detection
What non-microbial antigens exist?
-food molecules
-particles in inhaled dusts
-injected molecules (bites, syringe, etc.)
