Lecture 7 Chapter 11 Flashcards

1
Q

Where is heme iron found?

A

Only found in meat i.e. Steak

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2
Q

Where is non-heme iron found?

A

Spinach

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3
Q

How much iron do you need within your diet? And how much do you need per day?

A

10-20 mg in diet
1-2 mg/day

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4
Q

What does transferrin do?

A

Transports iron

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5
Q

You lose 1-2mg iron/day from what?

A

Desquamation of epithelia

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6
Q

After iron is absorbed where does it get transported and what percent of it is transported

A

75% - hemoglobin/erythropoiesis
10-20% - ferritin (stores iron in liver and hearts
5-15% - other processes

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7
Q

Name 2 examples of when women would need more iron

A

Post period
Pregnant

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8
Q

What is the role of hepcidin and where is it produced

A

Protein produced by the liver
Traps iron in cells/cytoplasm

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9
Q

Whole-body iron metabolism

A
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10
Q

What percent of total body iron is hemoglobin iron

A

~65%

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11
Q

What percent of total body iron is storage iron: hemosiderin, ferritin

A

~25%

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12
Q

Regulation of iron absorption

A
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13
Q

Transport and storage

A
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14
Q

Where is transferrin produced?

A

Liver

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15
Q

How does iron move from the body to an erythrocyte

A

Body iron stores serum ferritin
Transferrin birds to receptor
Transferrin delivers ion to hgb in developing erythrocyte

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16
Q

What stain is used on iron

A

Prussian blue

17
Q

What does ferritin do

A

Big, binds to iron, stores ferric iron

18
Q

What is hemosiderin

A

More oxidized than ferritin, harder to remove iron

19
Q

What is the arrow pointing at

A

Iron deposits

20
Q

How do you find the serum iron level

A

Total iron binding capacity - tagged ion

21
Q

How to find % tranferrin saturation

A

Iron/total iron-binding capacity (TIBC) x 100

22
Q

How do you find the unsaturated iron-binding capacity

A

Count the empty sides where a tagged iron is supposed to go

23
Q

What is acute phase reactant

A

Group of proteins
Level increases or decreases with chronic disease or inflammation

24
Q

Transferrin level result with chronic disease

A

Positive, increase

25
Q

Albumin level result with chronic disease

A

Negative, decrease

26
Q

Ferritin level result with chronic disease

A

Increase

27
Q

Lab assessment of serum transferrin receptors

A

Decreases a lot of storage
Increase, no iron serum

28
Q

What birds to free erythrocyte protoporphyrin

A

ZInc, no iron

29
Q

What 6 organs are affected when there is an iron overload

A

Pituitary
Thyroid
Heart
Liver
Pancreas
Gonads

30
Q

How does iron overload affect the pituitary

A

Impaired growth, infertility

31
Q

How does iron overload affect the thyroid

A

Hypoparathyroidism

32
Q

How does iron overload affect the heart

A

Cardiomyopathy, cardiac failure

33
Q

How does iron overload affect the liver

A

Hepatic cirrhosis

34
Q

How does iron overload affect the pancreas

A

Diabetes mellitus

35
Q

How does iron overload affect the gonads

A

Hypogonadism

36
Q

Iron panel

A