Lecture 7 Chapter 11 Flashcards
Where is heme iron found?
Only found in meat i.e. Steak
Where is non-heme iron found?
Spinach
How much iron do you need within your diet? And how much do you need per day?
10-20 mg in diet
1-2 mg/day
What does transferrin do?
Transports iron
You lose 1-2mg iron/day from what?
Desquamation of epithelia
After iron is absorbed where does it get transported and what percent of it is transported
75% - hemoglobin/erythropoiesis
10-20% - ferritin (stores iron in liver and hearts
5-15% - other processes
Name 2 examples of when women would need more iron
Post period
Pregnant
What is the role of hepcidin and where is it produced
Protein produced by the liver
Traps iron in cells/cytoplasm
Whole-body iron metabolism
What percent of total body iron is hemoglobin iron
~65%
What percent of total body iron is storage iron: hemosiderin, ferritin
~25%
Regulation of iron absorption
Transport and storage
Where is transferrin produced?
Liver
How does iron move from the body to an erythrocyte
Body iron stores serum ferritin
Transferrin birds to receptor
Transferrin delivers ion to hgb in developing erythrocyte
What stain is used on iron
Prussian blue
What does ferritin do
Big, binds to iron, stores ferric iron
What is hemosiderin
More oxidized than ferritin, harder to remove iron
What is the arrow pointing at
Iron deposits
How do you find the serum iron level
Total iron binding capacity - tagged ion
How to find % tranferrin saturation
Iron/total iron-binding capacity (TIBC) x 100
How do you find the unsaturated iron-binding capacity
Count the empty sides where a tagged iron is supposed to go
What is acute phase reactant
Group of proteins
Level increases or decreases with chronic disease or inflammation
Transferrin level result with chronic disease
Positive, increase
Albumin level result with chronic disease
Negative, decrease
Ferritin level result with chronic disease
Increase
Lab assessment of serum transferrin receptors
Decreases a lot of storage
Increase, no iron serum
What birds to free erythrocyte protoporphyrin
ZInc, no iron
What 6 organs are affected when there is an iron overload
Pituitary
Thyroid
Heart
Liver
Pancreas
Gonads
How does iron overload affect the pituitary
Impaired growth, infertility
How does iron overload affect the thyroid
Hypoparathyroidism
How does iron overload affect the heart
Cardiomyopathy, cardiac failure
How does iron overload affect the liver
Hepatic cirrhosis
How does iron overload affect the pancreas
Diabetes mellitus
How does iron overload affect the gonads
Hypogonadism
Iron panel
