Lab Quiz 3 Flashcards
Sickle cell or hemoglobin S
Hemoglobin C
Rectangular hemoglobin crystals
Hemoglobin SC
Irregular crystals, sickle cells, target cells
Hemoglobin E
MCV = 58; Hb = 13.5
Non-specific target cells
Neonate “kiddie” lymphs
Small naive lymphocytes
Normal lymphocytes
Reactive lymphocyte
Atypical lymphocyte
Reactive lymphocyte
Monocyte
Anaplasma phagocytophilum
Rodents natural hosts
Fever, severe headache, muscle pain, malaise
<1% fatal
Morula in neutrophils
Ehrlichia chaffeensis
Deer natural hosts
Fever and chills, severe headache, muscle pain, rash
3% fatal
Morula in monocytes
Bacteria
Bacilli, cocci, spirochete
Bacteria stain blue-purple with romanowsky stains
Rarely present in high enough numbers to be seen on peripheral blood smears
Fungi
Yeast: candida, cryptococcus, malassezia furfur
Dimorphic fungi: histoplasma capsulatum, penicillium marneffei
Candida albicans
Normal flora
Common cause of health-care associated sepsis
40-60% fatality
Causes respiratory infections and thrush
Histoplasma capsulatum
Biphasic mold
Environmental in nitrogen rich soil
Infection is problematic for immuno-compromised persons
Indicator of aids
Babesia microti
Babesia
Pyriform shapes
Teardrop pairs
Babesia
May form tetras or “Maltese crosses”
Not seen in malaria
Babesia
Cases with very high parasitemias may occur as extracellular aggregates
Can be confused with schizonts of plasmodia
A classical malaria attack lasts how long and consists of what?
6-10 hours
Consists of:
A cold stage (shivering)
A hot stage (fever, headaches, vomiting; seizures in young children)
A sweating stage (sweats, normal temp., tiredness)
What are 3 severe forms of malaria
Black water fever
Cerebral malaria
Severe anemia
What is the stain of choice for malaria parasites
Giemsa stain
What is an alternative to Giemsa stain
Wright stain
What does not show with a wright stain?
Schuffner’s dots
What kind of ph shows Schuffner’s dots better
Basic
Malaria P. vivax with wright stain
No Schuffner’s dots
Malaria P. vivax with Giemsa stain
Visible Schuffner’s dots
Malaria
P. falciparum
Malaria - P. falciparum ring stage
Malaria - P. vivax ring stage
Malaria - P. malariae ring stage
Malaria - P. oval ring stage
Malaria - P. falciparum trophozoite stage
Malaria - P. vivax trophozoite stage
Malaria - P. malariae trophozoite stage
Malaria - P. oval trophozoite stage
Malaria - P. falciparum schizont stage
Malaria - P. vivax schizont stage
Malaria - P. malariae schizont stage
Malaria - P. oval schizont stage
Malaria - P. falciparum gametocyte stage
Malaria - P. vivax gametocyte stage
Malaria - P. malariae gametocyte stage
Malaria - P. oval gametocyte stage
P. falciparum ring stage
Accolade cell can kill within 48 hours
P. falciparum gametocytes
Malaria rings
Malaria trophozoites
Malaria Trophozoites
Malaria gametocytes
Trypomastigote
Trypanosoma brucei
Trypanosoma cruzi
Holds feces
Common on US borders
More “S” shaped
Sickle cell
Often found with nucleated RBCs, target cells, and Howell-jolly bodies
Hemoglobin C
Rod-shaped cells
Often has spherocytes and target cells
Hemoglobin SC
Folded RBCs → look for crystals
Odd shapes → kind of look like schistocytes
Hemoglobin H
Hemoglobin Bart’s hydrops fetalis syndrome
B- thalassemia minor
Hypochromic, microcytic
Minor anemia
2 alleles missing
Usually contains target cells
Beta thalassemia intermedia
Contains nucteated RBCs and target cells
Treatment needed
B- thalassemia major (Cooley’s anemia)
Will need a blood transfusion
Can have elevated or normal cell count
Reactive lymphocytes
Monocyte
Infectious mononucleosis (“kissing disease”)
Increased lymphocytes
T-cells kill infectious B-cells
Epstein-barr virus
Viral infection
High lymphocyte count or low neutrophil count
Atypical lymphocytes
Pertussis “whooping cough”
Atypical lymph’s
Serum sickness
Dark blue cytoplasm
B-lymph
Crystallized antibody
Plasma cytoid
Platelets and platelet agglutination
Megakaryocyte fragments
Fragments and nRBCs