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CLS 307 > Lecture 4 Chapter 5 > Flashcards

Lecture 4 Chapter 5 Flashcards

1
Q

Where do stem cells live

A

Bone marrow

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2
Q

Every second you make how many cells

A

3 million

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3
Q

What is a pronormoblast

A

First differentiation from stem cell
Immature
Myeloid or lymphnode?

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4
Q

What happens once a cell becomes a basophilic normoblast

A

It cannot go back and be a pronormoblast

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5
Q

What is the last stage a RBC can divide

A

Polychromtophilic normoblast

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6
Q

What does proliferation mean

A

Can divide and make more of itself

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7
Q

At what stage is there no more proliferation

A

Orthochromic normoblast

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8
Q

What are the 7 stages of differentiation of a stem cell

A

1) pronormoblast
2) basophilic normoblast
3) polychromatophilic normoblast
4) orthochromic normoblast
5) shift reticulocyte-BM
6) reticulocyte - PB
7) erythrocyte

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9
Q

Characteristics of immature cells

A

Larger cytoplasm, blue
Basophilic
RNA makes it blue

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10
Q

How does the Wright stain work

A

It binds to acidic and makes it blue

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11
Q

What stage of cell and what is happening

A

Orthochromic normoblast
Diffused chromatin
Gene is actively being transcribed

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12
Q

What does supravital stain for?

A

Reticulocytes

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13
Q

What does the wright stain stain for

A

Polychromasia (blue tint)

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14
Q

How long does it take for a stem cell to start to divide

A

21 days

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15
Q

If there is a high count of reticulocytes what is not the problem

A

Problem not in the bone marrow

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16
Q

What are the 2 erythroid progenitors

A

Burst-forming unit-erythroid (BFU-E)
Colony-forming unit-erythroid (CFU-E)

17
Q

What are the 6 erythroid precursors

A

Pronormoblast
Basophilic normoblast
Polychromatic normoblast
Orthochromic normoblast
Reticulocyte
Erythrocyte

18
Q

What is the nomenclature and from what country are the 3 systems?

A

Erythroblastic - British
Normoblastic - American
Rubriblastic - European

19
Q

Name the RBC maturation stages

A
20
Q

What is the primary protein a pronormoblast makes?

A

Hemoglobin

21
Q

What is hypoxia

A

An absence of enough oxygen in the tissues
A stimulant for erythropoiesis

22
Q

Describe the erythrokinetics cycle

A
23
Q

What do you have more of once you end your period

A

Erythropoietin

24
Q

How long does differentiation and maturation from a basophilic erythroblast take

A

5 to 7 days

25
Q

What % of evythroid precursors never mature and are destroyed and why?

A

10-15%
They don’t make it out of the bone marrow
Go into a resivoir for RBCs
Recycled

26
Q

What % of RBCs are broken down by extravascular hemolysis and where does it happen

A

90%
Happens in organs/tissue: spleen and liver

27
Q

What % of RBCs are broken down by intravascular hemolysis and how does it happen

A

10%
Cells fall apart or get destroyed inside the blood vessel

CLS 307 (21 decks)

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