Lecture 7 - Antibodies in Infection

Question 1

Secondary Lymphoid Organs: Filter and Response Factories?

Answer 1

Spleen (blood filter), lymph nodes (tissue filter), Peyer’s patches (gut filter)

Question 2

Dendritic Cells?

Answer 2

Collect antigen and present it at lymph node

Question 3

B lymphocyte function?

Answer 3

Antibody production

Question 4

CD8 T Lymphocyte Function?

Answer 4

Antigen-specific toxicity

Question 5

K Lymphocyte function?

Answer 5

Antibody-Dependent Cellular Cytotoxicity

Question 6

CD4 T Lymphocyte function?

Answer 6

Cytokine production

Question 7

Antibody divisions?

Answer 7

Light chain (constant and variable region), Heavy chain (3 constants and 1 variable region, hinge region)

Question 8

CH2 function?

Answer 8

Complement-binding region

Question 9

FC region?

Answer 9

Area below hinge region, constant between antibodies, is recognised by neutrophils to enhance phagocytosis

Question 10

B Cell Clonal Activation?

Answer 10

@ 2ndary lymph organ, new antigen presents, B cell produce new receptors to fit and ‘asks for help’ from T cell to identify danger, if dangerous proliferates and differentiates into: plasma cells (antibody production) and memory cells

Question 11

Direct neutralisation?

Answer 11

Viruses, coating w antibodies changing its shape so it cannot enter a cell

Question 12

Opsonisation?

Answer 12

Bacteria, binding site of antibody attaches to cell surface of antigen, FC region is exposed and enhances neutrophil phagocytosis w Fc receptors

Question 13

Antibody Dependent Cellular Cytotoxicity?

Answer 13

Bacteria, similar to opsonisation, except exposed FC attracts K cell Fc receptors which releases short range toxic factors