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Principles of medicine > Lecture 34 - Non-coding RNA and Disease > Flashcards

Lecture 34 - Non-coding RNA and Disease Flashcards

1
Q

ncRNAs involved in?

A

pathogenesis (development and progression of disease), therapeutics (treatment of disease) and biomarkers (diagnosis and prognosis of disease)

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2
Q

small ncRNA types?

A

tRNA (protein translation), snoRNA (modify rRNA and tRNA - ribosome biogenesis), miRNA (repres translation of oncogenes + TSG)

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3
Q

microRNA (miRNA) and cancer?

A

repress translation of oncogenes and tumour suppressors

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4
Q

long ncRNAs?

A

XIST (x-linked chromosome inactivation), HOTAIR (increased expression in breats cancer - methylation), H19 (maternally expressed imprinted RNA)

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Principles of medicine (30 decks)

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