Lecture 4 - Chronic Inflammation

Question 1

Clinical presentations of acute inflammation (local effects)?

Answer 1

redness, swelling, heat, pain, loss of function

Question 2

Clinical presentations of inflammation (systemic effects)?

Answer 2

fever, leukocytosis, acute phase proteins from liver, increased glucocorticoid steroid hormones

Question 3

Inappropriate inflammatory responses?

Answer 3

Rheumoid artheritis, atherosclerosis, hypersensitivity to toxins, hyper-immune reactions

Question 4

Macrophage characteristics?

Answer 4

Monocytes that enter the injured tissue, greater phagocytic potential than neutrophils, interface closely w lymphocytes

Question 5

Granuloma?

Answer 5

specific pattern of chronic inflammation seen in diseases just such as tuberculosis

Question 6

Granuloma formation?

Answer 6

core of necrosis, aggregations of macrophages turn into epithelium-like cells (epithelioid macrophages), collar of lymphocytes surround, macrophages fuse together to make giant cells

Question 7

Directions of injured tissue after inflammation?

Answer 7

resolution (tissue to normal); repaor (organisation into granulation tissue -> non-functional fibrous scar); regeneration (tissue structure and function rebuilt to some previous function)