Lecture 29 - Familial Cancer

Question 1

Indicators of familial cancer?

Answer 1

involvement of close relatives, successive generations, young age onset, multiple types of cancers

Question 2

Once both alleles are deleted?

Answer 2

increased mutation rate, alterations to cell regulatory gene numbers incresing risk of cancer leding to microsatellite instability

Question 3

Breast cancer genetics and male cancer risk??

Answer 3

BRCA-1: prostate 6% increase; BRCA-2: prostate 10% increase, breast 6%