Lecture 4: Receptor Antagonism Flashcards
1
Q
Receptor Antagonism
A
-Drug-receptor interaction that interferes with or prevents the development of a drug response by an agonist
2
Q
Three types of antagonists
A
-competitive
-noncompetitive
-irreversible (non-competitive)
3
Q
Competitive antagonism
A
-reversible equilibrium competitive
-combines with same site on receptor as agonist
4
Q
Competitive antagonism reversal
A
increase dose of AGONIST
5
Q
log dose-response curve in presence of competitive antagonist
A
-shifts to the right
-change Km not Vmax maybe
-reduction of effective potency of agonist
