Lecture 1: Intro to ADME

Question 1

ADME

Answer 1

-Absorption
-Distribution
-Metabolism
-Excretion

Question 2

How to quantify drug effect

Answer 2

-Onset
-Duration
-Intensity

-determined by concentration vs time profile

Question 3

Dosage form to effect

Answer 3

-release
-dissolution
-degradation
-absorption
-excretion
-distribution

Question 4

Pharmacokinetics

Answer 4

study of ADME of xenobiotics

Question 5

Pharmacodynamics

Answer 5

-study of EFFECTS and ACTION of xenobiotics

Question 6

Minimum effective concentration range (MEC on graph)

Answer 6

concentration of drug that gives minimum effect

Question 7

Duration

Answer 7

time the graph is above MEC

Question 8

slide

Answer 8

10

Question 9

drug disposition

Answer 9

fate of drug after entering systemic circulation

Question 10

Pharmacotherapeutics

Answer 10

-pathophysiology
-pharmacodynamics
-pharmacokinetics

Question 11

Routes of administration

Answer 11

-Ingestion
-Inhalation
-Dermal
-Parenteral (Injection)

Question 12

Reduction in extent of absorption impacts

Answer 12

intensity

Question 13

reduction in the speed of entry into systemic circulation impacts

Answer 13

onset

Question 14

speed and extent of distribution impacted by

Answer 14

-barriers
-blood flow

Question 15

Outcomes of metabolism

Answer 15

-active drug to inactive metabolite
-active to active
-inactive to active
-active to REactive

Question 16

Routes of Excretion

Answer 16

-renal (primary) or Biliary to feces
-also pulmonary, salivary, mammary

Question 17

Which antibiotic would be the better choice in
a patient with renal failure?

-eliminated in bile
-eliminated in urine

Answer 17

eliminated in bile

Question 18

Why is ADME important

Answer 18

-use of preclinical models to predict ADME = lot less drug failure

Question 19

Active drug to inactive metabolite

Answer 19

phenobarbital to hydroxyphenobarbital by hydroxylation

Question 20

Active drug to active metabolite

Answer 20

procainamide to N-acetylprocainamide by acetylation

Question 21

inactive drug to active metabolite

Answer 21

codein to morphine by demthylation

Question 22

active drug t reavtive metabolite

Answer 22

-acetaminophen to reactive metabolite by

Question 23

Enteric coated aspirin

Answer 23

coating reliant on pH to dissolve
-WAIT until small intestine
= SLOWER