Lecture 4: Excretion Flashcards
major routes of excretion
-renal (primary)
-bile to feces
other routes of excretion
-pulmonary
-salivary
-mammary
Nephron
-primary functional unit of kidney
-compact
mechanisms of renal excretion
-filtration
-active tubular secretion
-tubular reabsorption
-biotransformation
Filtration location
-glomerulus
tubular secretion location
-proximal convuluted tubule
tubular reabsorption location
-distal convuluted tubule
-collecting duct
Glomerular filtration
Determinants of Filtration
-number of functional nephrons
-size (<5000)
-protein binding (permeability)
-renal blood flow (delivers drug to kidney)
Old people have less nephrons
-reduce dose
-less excretion
Renal Clearance vs weight graph
-negative slope
-increase weight decreases clearance rate
Renal clearance vs Creatinine Clearance
-positive slope
-increase together
Decrease creatinine clearance
-decrease renal clearance by filtration
= lower dose
Active Tubular Secretion
-carrier-mediated transport
-some filtration still
-susceptible to competitive interactions
-stereoselective excretion
carrier-mediated reactions (ATS)
- saturable
- competitive interactions (only certain amount of carriers available = drug interactions)