Lecture 3: Distribution Flashcards
concentration vs time cuves: drug distributes to and is restrivted to these tissues (INITIAL COMPARTMENT)
-constant slope downwards
concentration vs time cuves: drug distributes to tissues at different rates (AFTER FULL DISTRIBUTION)
-curved increase and decrease
what causes the offset of the pharmacologic effect for thiopental?
-driven by redistribution of drug
-hits peak concentration in brain then redistributes concentration to lean tissue
perfusion rate limited
-how quickly drug can be delivered
permeability rate limited
-how quickly drug moves across membrane
which condition shows slower tissue distribution
permeability rate limited
Convection
-rate related to pressure
Diffusion
-rate related to concentration
which method of transport is likely to be important for monoclonal antibodies?
-convection
-increase pressure = increase gaps to push big molecules out
Movement of drug within blood
-drug can be free, bound, inside cells, etc
-only free drugs can get across membranes
Shift tissue binding or plasma protein binding
-change distribution of drugs
most drugs in tissue is bound to:
-nonspecific sites and not receptors
Sites of action
-plasma (epithelial barrier)
-intersitial space (cappilary barrier)
-intracellular (membrane barrier)
Adverse reactions to phenytoin (antiseizure) increases
as serum albumin decreaases
drug trapping
-changing equilibrium between compartments by using differences in ptoyonation states/pH environments