Lecture 2

Question 1

when was the first death of ebola and where

Answer 1

Dec. 2013, first death was a 2 year old girl who died in Geuckedou.

Question 2

which villages did ebola spread to

Answer 2

Gueckedou, Macenta, Kissodougou

Question 3

which countries did ebola spread

Answer 3

started in guinea and then liberia and sierra leone

Question 4

how many deaths for ebola

Answer 4

7000

Question 5

true or false: we have a poor immune response against tropical diseases

Answer 5

true that is why iy is hard to make vaccines againsts them

Question 6

what is the rate at which people die from ebola

Answer 6

1/3

Question 7

why did ebola stop spreading

Answer 7

behavioral change
-no more burial rituals
-those with symptoms would go to isolation centers and get diagnosis by pcr

Question 8

Why was it possible to control EBOLA but not COVID ?

Answer 8

-different transmission route
-more travelling in that arre
-asymptomatic people can still spread covid

Question 9

true or false: moist emergin infectuous diseases are zoonotic

Answer 9

true

Question 10

Spread of EIDs is much ….. than previously

Answer 10

faster

Question 11

Medical interventions are … ….. for EIDs

Answer 11

not available available

Question 12

true or false: poor are the first to suffer from EIDs

Answer 12

true
except for covid where everyone was fucked

Question 13

how many people died of covid

Answer 13

20 million

Question 14

how many people die of tb per year

Answer 14

2 million

Question 15

how much money for covid vaccine

Answer 15

100 billion dollars

Question 16

how much money for tb vaccine

Answer 16

0.1 million dollars

Question 17

who and when was leish discovered

Answer 17

-William Leishman
-Charles Donovan
1900

Question 18

what does kala azar means

Answer 18

dark illness

Question 19

who found the sandly vector and when

Answer 19

major stinson
1920

Question 20

1800s Originally called British disease because….

Answer 20

vl followed colonization by the british in northern india

Question 21

which disease did people think VL was

Answer 21

malaria

Question 22

VL is caused by what

Answer 22

Ld

Question 23

life cycle of Ld

Answer 23

-starts as promastigote with flagella in the gut of the fly: gets massive replication
-after bloodmeal gets transmitted to human and gets in macrophage
-replicated in the macrophage and becomes an amastigot aka sheds his tail
-then infects other macrophages and etc

Question 24

true or false visceral leish is anthroponotic

Answer 24

yeah it is stage 5

Question 25

true or false: humans are the only reservoir of Ld

Answer 25

yeah

Question 26

visceral leish affects what

Answer 26

liver and sleen, you die in approx a year

Question 27

Visceral Leishmaniasis, caused by…….

Answer 27

Leishmania infantum

Question 28

what is the reservoir of Leishmania infantum

Answer 28

doggie

Question 29

where is visceral leish caused by L.i?

Answer 29

Brazil, Southern Europe and North Africa

Question 30

true or false visceral leish caused by L.i is zoonotic

Answer 30

true

Question 31

what is the reservoir for cutaneous leish

Answer 31

rodents aka it is zoonotic

Question 32

name come species that cause cutaneous leish

Answer 32

L. major, L. mexicana
L. Braziliensis + others

Question 33

why is there a cutaneuous disease in leish

Answer 33

-different genetic differences between species
-the parasites are not adapted to survine in humans aka it stays on the skin for like 6 months then leave

Question 34

what is the disease progression of mucocutaneous leish

Answer 34

-starts as cutaneous and then years later it reactivates and staus in the nose
-the strong immune response is the cause of the nose destruction