Lecture 2 Flashcards
when was the first death of ebola and where
Dec. 2013, first death was a 2 year old girl who died in Geuckedou.
which villages did ebola spread to
Gueckedou, Macenta, Kissodougou
which countries did ebola spread
started in guinea and then liberia and sierra leone
how many deaths for ebola
7000
true or false: we have a poor immune response against tropical diseases
true that is why iy is hard to make vaccines againsts them
what is the rate at which people die from ebola
1/3
why did ebola stop spreading
behavioral change
-no more burial rituals
-those with symptoms would go to isolation centers and get diagnosis by pcr
Why was it possible to control EBOLA but not COVID ?
-different transmission route
-more travelling in that arre
-asymptomatic people can still spread covid
true or false: moist emergin infectuous diseases are zoonotic
true
Spread of EIDs is much ….. than previously
faster
Medical interventions are … ….. for EIDs
not available available
true or false: poor are the first to suffer from EIDs
true
except for covid where everyone was fucked
how many people died of covid
20 million
how many people die of tb per year
2 million
how much money for covid vaccine
100 billion dollars
how much money for tb vaccine
0.1 million dollars
who and when was leish discovered
-William Leishman
-Charles Donovan
1900
what does kala azar means
dark illness
who found the sandly vector and when
major stinson
1920
1800s Originally called British disease because….
vl followed colonization by the british in northern india
which disease did people think VL was
malaria
VL is caused by what
Ld
life cycle of Ld
-starts as promastigote with flagella in the gut of the fly: gets massive replication
-after bloodmeal gets transmitted to human and gets in macrophage
-replicated in the macrophage and becomes an amastigot aka sheds his tail
-then infects other macrophages and etc
true or false visceral leish is anthroponotic
yeah it is stage 5
true or false: humans are the only reservoir of Ld
yeah
visceral leish affects what
liver and sleen, you die in approx a year
Visceral Leishmaniasis, caused by…….
Leishmania infantum
what is the reservoir of Leishmania infantum
doggie
where is visceral leish caused by L.i?
Brazil, Southern Europe and North Africa
true or false visceral leish caused by L.i is zoonotic
true
what is the reservoir for cutaneous leish
rodents aka it is zoonotic
name come species that cause cutaneous leish
L. major, L. mexicana
L. Braziliensis + others
why is there a cutaneuous disease in leish
-different genetic differences between species
-the parasites are not adapted to survine in humans aka it stays on the skin for like 6 months then leave
what is the disease progression of mucocutaneous leish
-starts as cutaneous and then years later it reactivates and staus in the nose
-the strong immune response is the cause of the nose destruction
