Lect 4 Flashcards

1
Q

what is ambisome used for

A

treatment for visceral leish
-it is a one shot treatment thing
-intravenous injection
-made by gilhead

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2
Q

what is post kala azar dermal leish

A

-pkdl
-10% of people who got cured after visceral leish
-looks like lil dots
-parasites are in low quantity on the skin

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3
Q

true or false: there is more asymptomatic cases than clinical cases

A

true it is like 5-20 cases for 1 clinical case

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4
Q

what is the immune response to leish

A

-activated dc activates CD4 t cells
-activate th1 cells
-get il2 and inf gamma
-activate macrophages and you have inos
-macropage kills parasite

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5
Q

what happens when you have leish and HIV

A

-no more cd4
-you get il4
-activates th2-get more il4
-activates B cells
-you get antibodies
-parasite survival
-shitty outcome

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6
Q

what does imiquimod do

A

activates TLRs 7/8 in phagolysosome
-ssrna is natural ligand for tlr 7/8
-you push for the best outcome
-it also activates macrophages for inos

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7
Q

what is aldara

A

-imiquimod topical cream
-treats cutaneosu leish

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7
Q

where are the parasites in the macrophages in leish

A

phagolysosome

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8
Q

true or false: imiquimod fucks up leish

A

true but depends on what it is used for

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9
Q

imiquimod % of slay

A

-increases rate of sucess with antimony
-around 72% to 75%

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9
Q

what is the % of slay of aldara

A

30%

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10
Q

what is the tlr 9 agonist

A

cpg currently in clinical trials to treat leish

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11
Q

imiquimod is also used for what other than leish

A

-slays against dengue
-when applied as a cream on skin after bite
-it activates macrophages

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12
Q

when was the cause of malaria discovered

A

-charles laveran
-in 1886
-found that it was a parasite cuz he was a slay at microscope

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13
Q

when did laveran win his nobel

A

in 1907

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14
Q

what did people think malaria is from

A

bad air

15
Q

what did ronald ross discover

A

-in 1897
-that it was the mosquito anopheles that caused malaria
-aka the transmission

16
Q

what did laveran see under the microscope

A

gametocystes

16
Q

when did ross win his nobel

A

1902

17
Q

what did ross find under the microscope

A

sporozoites

18
Q

plasmodium life cycle

A

Sporozoites get injected
Go into the blood into the liver
Transforms into merozoites
Pour out of the liver and gets into red blood cells
Replicates fucking fast
Gets out and transforms into gametocytes (convert into haploid) that gets taken up by the mosquito

19
Q
A
20
Q
A