Lecture 2 Flashcards

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1
Q

A disease that is always present at low levels in a restricted area of the world is known as

A

an endemic disease

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2
Q

A mutualistic relationship exists between human hosts and

A

microbiota

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3
Q

A particular flu strain spreads easily from person-to-person and also has high mortality. Which of the following is true of this flu strain?

A

It has high infectivity and high virulence

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4
Q

Ebola epidemics occasionally occur. Where does the virus that causes Ebola “hide” in between epidemics? It is thought that bats harbor the virus, and thus bats are

A

a reservoir

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5
Q

Pathogen A has an LD50 of 1,000, and pathogen B has an LD50 of 75. Which of the following is true?

A

Pathogen B is more virulent than pathogen A

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6
Q

HIV can be transmitted via the ___________ route during sexual contact or via the ____________ route during needle sharing.

A

urogenital, parenteral

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7
Q

The human protein Transferrin sequesters iron (used for replication) away from bacteria. Transferrin attempts to interfere with which fundamental attribute of a successful pathogen?

A

nutrient acquisition

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8
Q

Walter defecates in the company restroom, does not wash his hands thoroughly, and then uses the office coffee pot, transferring bacteria onto the handle of the pot. Maria pours some coffee, and then goes to her desk to eat a muffin, ingesting some of the bacteria she picked up from the coffee pot. Which of the following is true of Maria’s bacterial infection?

A

The infection occurred via indirect contact

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9
Q

What might allow disease vectors such as mosquitoes to increase their global geographic range?

A

An expansion of suitable habitat due to climate change

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10
Q

Name the stages of infectious disease in the correct order.

A

incubation phase, prodromal phase, illness phase, decline phase, convalescent phase

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11
Q

An infection that is the result of a pathogen that was acquired in a hospital is

A

an Nosocomial infection

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12
Q

Any bacteria, virus, fungus, protozoa, or worm that causes disease is a ?

A

Pathogen

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13
Q

Ability of an organism to cause disease

A

Pathogenicity

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14
Q

Measure of the degree/severity of a disease

A

Virulence

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15
Q

Attachment definition

A

Microbial adhesins must bind to receptors on host surface

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16
Q

Failure of a microbe to attach is known as ?

A

Expelled

17
Q

Immune Avoidance

A
  1. Pathogens can change surface antigens to confuse immune system (Salmonella)
  2. Pathogens can “talk” to cells and initiate cytokine release for an “all is well signal” (Staph)
  3. Intracellular parasites can signal apoptosis (Shigella)
18
Q

An example of nutrient acquisition

A

“Siderophores” have evolved ways to steal iron from a host for their own purpose

19
Q

Endemic

A

Always present in a community at low rate

20
Q

Epidemic

A

Many cases develop in a short time

21
Q

Pandemic

A

Epidemic spreads worldwide

22
Q

Reservoirs

A

Animal or environment that harbors pathogens

23
Q

Direct transmission

A

Touching, kissing, sex, aerosol

24
Q

Indirect transmission

A
  1. Fomites- inanimate object
  2. Vehicle- food & water
  3. Vector- ticks, mosquitos
25
Q

Portal

A

Preferred entry and exit

26
Q

Parenteral portal

A

Injection, insect bites, wound/needle stick

27
Q

Fomite

A

Inanimate object

28
Q

Vehicle

A

Food & Water

29
Q

Vector

A

Bug, ticks, mosquitos