Lecture 13 Flashcards
What waves and what hz in each sleep stage (including wakefulness)
- Wakefulness has Alpha (8-12hz) and beta (13-30hz) waves
1. Stage 1 has theta (3.5-8hz) waves
2. Stage 2 has sudden sleep spindles (12-14hz) with high activity and K-cpmplexes
3. Stage 3/4 has delta (<3.5Hz) waves.
4. REM has theta (3.5-8Hz) waves and beta (13-30Hz) waves - Then you return to stage 1/2
What location activates visual images in REM sleep? What happens when woken up(2)? Why can you not think rationally? What kind of dreams?
- LGN in the thalamus
- Woken up by meaningful stimuli
- When woken up you are alert and remember the dream
- No rational thinking due to reduced activity in fontal lobe
- Adventure-like, Narrative-like dreams
What happens to outside stimuli in stage 3/4 sleep? What happens when you wake up(2)? What particular kind of sleep usually happens here?
- All outside stimuli (also meaningful ones) are suppressed.
- When you wake up you are fussy and probably cannot remember the dream
- This is when nightmares happen. Because It has very emotional dreams.
What do astrocytes to during slow wave sleep and what do they do when energy is running out?
- Astrocytes build up the sugar supply for providing brain cells with energy.
- Astorcytes signal nerve cells to stop firing (adenosine) to preserve energy when the sugar supply is running low
What are 4/5 symptoms of sleep deprivation?
- Loss of thermoregulation (lower body regulation)
- Increased metabolism to increase temperature
- Severe weight loss
- Immune system disruption
- Death
What is the difference in the kind of learning between Slow wave and REM sleep
- Declarative learning in Slow Wave Sleep
- Non-Declarative learning in REM sleep
What are 3 functions of REM sleep
- Short moment of alertness to be aware of dangers
- Related to brain development (more REM sleep in children)
- Learning of non-declarative things.
What are the 4 (+5th) wakefulness neurotransmitter systems and how do they keep you awake?
- Acetylcholine From Brain stem and Forebrain in pons to all brain regions
- Serotonin: From Ralph nuclei in pons to all brain regions.
- Norepinephrine: From Locus Coeruleus in pons to all brain regions
- Histamine: From Tuberomammilary nucleus in the hypothalamus to all brain regions
- Orexin: From lateral Hypothalamus to the arousal systems do increase wakefulness
What is the Flip-Flop system of sleep and what is the Sleep region called? How does Orexin stabilize the system? How does adenosine interact with this?
- The Ventrolateral preoptic area VLPOA inhibits the arousal systems to make you fall asleep
- But the arousal systems can also inhibit the Ventrolateral preoptic area to not fall asleep.
- Orexin stabilizes the system by activating arousal systems when you want to stay awake (impaired in narcolepsy patients)
- Adenosine increases the activity in the Ventrolateral Preoptic area VLPOA to increase sleep.
How does the Flip-Flow system of REM sleep work?
- The SLD activates REM sleep
- the vlPAG inhibits REM sleep
How does the SLD (REM-ON) activate REM behaviors? What is muscle weakness called?
- It activates the system to increase genital activity
- It activates a system to activate the brain through acetylcholine and activate Rapid Eye Movements.
- It activates a system in the spinal cord to inhibit motor neurons so you cannot move the muscles (atonia)
How do the two flip-flop systems interact? What other region connects to the REM-ON system?
- If the vlPOA wins from the arousal system, you fall asleep
- It then starts inhibiting the Orixinergic neurons and vlPAG (REM-OFF) neurons.
- Eventually the vlPAG is so inhibited that the SLD wins and activates REM sleep.
- The Amygdala also controls the SLD (REM-ON system)
What kinds of sleep disorders are there for slow wave sleep (3) REM sleep (1) and Instable flip-flop?
- Slow wave sleep has somnambulism, bedwetting and nightmares
- REM sleep has REM sleep Behavior disorder (acting out dreams)
- Instable Flip-Flop has NArcolepsy.
What are 4 symptoms of Narcolepsy
- Sleep attacks: sudden need to sleep
- Cataplexia is sudden atonia (paralyzation) during wakefulness and mostly in high arousal
- Pre and Post sleep paralysis: atonia just before and after falling asleep
- Hypnagogic hallucinations: sleeping just before or after falling asleep
When and why does cataplexia activate?
- When you become aroused/emotional, the flip-flop systems thinks you have entered REM sleep and paralyzes the muscles (atonia).