lecture 12 cancer in the GI Flashcards
most common tumours of the GI
adenocarcinome
symptoms of GI cancer
wightloss
bleeding
pain
alteration of flow
alterations of flow
dysphagia
diarrhoea
constipation
occult poo
when you cant see it
epigastric pai
foregut
periumbiliacal pain
midgut
pain of cancer
visecral - poorly localised
usual spread
liver and lungs
risk factors
diet - high carb and fat smoking alcohol inflammation genetic
familial cancers
HNPCC
FAP
oesophagus is lined with
squamous epithelium
where do you find oesophageal squamous carcinoma
middle
where are oesophageal adenocarcinomas
typically lower down
adenocarcinoma of the oesophagus
barrettes
in adenocarcinoma what is the change of the epithelium
squamous to columnar
symptoms of oesophageal cancer
difficulty swallowing
pain on swallowing
odynophagia
risk factors of pancreatic cancer
smoking
diabetes
chronic pancreatitis
oncogene almost always mutated in pancreatic
KRAS
tumour suppressor affected in pancreatic
CDKN2A
pancreatic symptoms
unlikely
pain
obstructive jaundice
Migratory thrombophlebitis
is inflammation of superficial veins and appears in different places
sign of pancreatic malignancy
Migratory thrombophlebitis
neoplastic colon polyps
adenocarcinoma
FAP inheritance
autosomal dominant
FAP mutation
APC
APC is in cahrge of
beta catalyn and the wnt signalling
lynch syndrome
HNPCC
in HNPCC where is the problem
DNA mismatch repair
what increases chance of malignancy with polyps
the size
intestinal type gastric cancer mutation
increase in wnt signalling
diffuse infiltrative type gastric cancer mutation
E-cadherin (CDH1)
