lecture 11 drugs and the gut Flashcards
1
Q
hydrolysis
A
breaking down drugs using water
2
Q
reduction
A
loss of oxygen
3
Q
oxidation
A
gain of ooxygen
4
Q
intrinsic clearance
A
clearing unbound drug
5
Q
drug that can change prothrombin time
A
paracetamol
6
Q
flow of blood in the liver
A
periportal to perivenous
7
Q
which way does bile flow
A
opposite way to the blood
8
Q
what is on the other side of the endothelial cells
A
space of disse
9
Q
where is oxygen high in the liver
A
peiportal end
10
Q
where is glycolysis
A
hepatocytes
11
Q
where is urea formed
A
periportal region
12
Q
where is ammonia changed in the liver
A
perivenous end
13
Q
what is ammonia changed into
A
glutamine
14
Q
where is oxidative phosphorylation and gluconeogenesis
A
periportal end
15
Q
how can we excrete drugs
A
bile or urine
16
Q
what must an oral drug be to enter the blood
A
lipid soluble
