Lecture 12 Flashcards
What is the rate of bulk erosion?
rate of water into the polymer is > rate of transformation into a water soluble material
What is the rate of surface errosion?
rate of water into polymer < rate of transformation into a water soluble material
Is bulk erosion a linear or nonlinear mass loss?
nonlinear
How does bulk erosion affect the material?
It gets less and less dense, it almost forms pores, but the general size is about the same
How does surface erosion affect the size of the material?
It greatly impacts the size and makes the material smaller
Is surface erosion a linear or nonlinear mass loss?
maybe linear but depends on geometry
What properties control degradation?
polymer hydrophobicity, MW, polymer structure, enzyme concentration, fabrication (e.g. surface area)
Why/how can materials be used in studies of mechanobiology?
Motivation for materials in mechanobiology
Basic materials/ polymers/ mechanical testing
Highlight on hydrogels
Cell behavior with materials – 2D/3D
Materials processing –3D printing, electrospinning
What is the relationship of hydrophobicity to polymer degradation?
What is the relationship of hydrophobicity to polymer degradation?
What is the relationship of MW to polymer degradation?
What is the relationship of enzyme concentration to polymer degradation?
What is the relationship of polymer structure to polymer degradation?
True/False: We now know the ECM plays an active role in cell signaling and behavior
True
True/False: ECM is specific to tissue and function.
True
How does ECM behave in bone?
It is mineralized
How does ECM behave in the cornea?
transparent
How is ECM produced and degraded?
by cells
What materials are commonly found in the ECM?
polysaccharides and fibrous proteins
What role do polysaccharides have in the ECM?
transport and compressive properties
What role do fibrous proteins have in the ECM?
structure and adhesion
True/False: ECM is diverse and heterogeneous.
True
What is the definition of mechanobiology?
study of mechanisms by which cells sense and
respond to mechanical signals
What does mechanobiology describe?
How physical factors, such as forces and mechanics, are able to influence biological
systems at the molecular, cellular, and tissue level.
