Lecture 10: Doctors, Science and Patients Flashcards

1
Q

Who is Wilder Penfield? What did he do?

A

Neurosurgeon inMontreal, mapped the brain ins search of the scientific basis for the human soul.

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2
Q

What was the rise in brain dissections due to?

A
  • large patient populations
  • you’ve got overcrowding and abandoned bodies
  • overcrowding provided large populations for observation and bodies for experiments.
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3
Q

What was cerebral localization?

A

tendency to look for lesions in the brain with the 19the century craze for studying parts of the brain under microscope to see the brain as a place where mental diseases existed.

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4
Q

What were 6 somatic (bodily) therapies?

A
  1. Hydrotherapy
  2. Malaria fever therapy
  3. Insulin coma therapy
  4. Metrazol/cardiazol convulsion therapy
  5. Electroconvulsive therapy
  6. Psychosurgery
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5
Q

What are the two types of hydrotherapy?

A
  1. the back

2. shock treatment (spray therapy)

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6
Q

When was hydrotherapy implemented in Canada?

A

1900-1910

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7
Q

Was was the bath with hydrotherapy?

A

soaking and ‘continuous baths’ used to calm agitated and aggressive patients.

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8
Q

What was hydrotherapy as shock treatment?

A
  • shock by spraying
  • immediate impact of relief by no long-term reduction in symptoms
  • sometimes used as punishment
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9
Q

Who invented fever therapy?

A

‘invented’ by Julius Wagner-Jauregg, an Austrian psychiatrist, in 1883

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10
Q

What did Wagner-Jauregg suggest a relationship between? Explain.

A
  • a relationship between ‘fever’ and psychosis
  • fever would reduce psychosis
  • when people got other illnesses, they would observe that fevers reduced mental symptoms
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11
Q

When was malaria therapy instituted?

A

1917

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12
Q

What happened with malaria therapy?

A

injected patient with malaria-infected blood to produce fever

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13
Q

Who invested malaria therapy?

A

Wagner-Jauregg

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14
Q

What did Wagner-Jauregg receive for malaria therapy in 1927?

A

The Novel Prize

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15
Q

How did Wagner-Jauregg discover malaria therapy?

A

One of his patients was a soldier suffering form shell shock who also contracted malaria. WJ took some of his soldier’s malaria infected blood and injected it into one of his patients with near-syphillis. After sever attacks of fever, the patient’s psychotic symptoms subsided.

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16
Q

What did malaria fever therapy reinforce?

A

Reinforced that made this was a medical problem, not behavioural.

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17
Q

When was insulin discovered and by whom?

A

Insulin was discovered in 1922 by Banting and Best.

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18
Q

Where was insulin discovered?

A

In Canada

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19
Q

How did insulin therapy work? What were they given rouse them from their comas?

A

Insulin causes the muscles to take up glucose from the blood if too much glucose is withdrawn, the patients will go into a hypoglycaemic coma. The com seemed to have therapeutic benefits that relieved patients of some their symptoms. They were given a sugar solution to rouse them from their coma.

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20
Q

When did insulin coma therapy become a treatment modality?

A

In the 1920s

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21
Q

Who was insulin often given to?

A

Insulin was often given to patients with depression, or those with little or no appetites (insulin would stimulate healthy responses).

22
Q

Who was Manfred Sakel?

A

Austrian medical graduate who studied diabetic morphine addicts in the 1930s.

23
Q

What did Sakel observe?

A

That 4-5 comas calmed 70% of schizophrenic patients. He noticed that comas produced by too much insult seemed to provide relief. He determined that the coma reduced symptoms and also had long term social benefits.

24
Q

What was the first true ‘convulsive therapy’?

A

metrazol (cardiazol) therapy

25
Q

Who is Ladislas von Meduna?

A

A Budapest psychiatrist who practiced convulsive therapy in 1934. He studied epilepsy and schizophrenia, finding that the two disorders and a curious relationship, the onset of an epileptic reaction seemed to reduce symptoms of schizophrenia and vice versa.
-idea was that patients with epilepsy did not have psychotic symptoms

26
Q

What drug was first used to induce seizures?

A

Camphor

27
Q

By 1935, __of__patients improved with convulsive therapy with camphor.

A

10 of 26

28
Q

What were the side effects of convulsive therapy with camphor?

A

vomiting, pain, unpredictability

29
Q

What happened with convulsive therapy switched to using metrazol or cardiazol?

A

Found similar rates of success, with fewer side effects. The problem was that the drug had a lower rate of reliability in terms of inducing a convulsion (why it never caught on).

30
Q

Who was Ugo Cerletti?

A

Professor of psychiatry in Rom in the 1930s. He studied epilepsy and schizophrenia and effect of convulsion on psychotic symptoms. (Electroconvulsive Therapy)

31
Q

Describe the early experiments of Ugo Cerletti?

A

Experiments on stray dogs for 6-7 years

32
Q

When was Ugo Cerletti’s first human ECT case?

A

1938

-man suffering from hallucinations recovered after three sessions

33
Q

Which had a better recovery rate: ECT or Metrazol therapy?

A

ECT

34
Q

What were the side effects of ECT? When did this change?

A

Similar side effects to Metrazol Therapy until the introduction of anaesthesia.

35
Q

When is ECT used widely throughout asylums?

A

1950s

36
Q

What is ECT used for today?

A

major depressive disorder with psychosis

37
Q

The was ECT uncommon? When did it begin to rise?

A

Uncommon in 1930s and rises towards 1940s.

38
Q

Who is Egaz Moniz?

A

Head of Neurological Institute of Lisbon (Portugal) who was interested in the frontal lobe.

39
Q

Why was Egaz Moniz interested in the frontal lobe?

A

Not just apparent relief offered by convulsions, fevers, or comas, but in cerebral localization: relationship between brain and activity. Led Moniz to study frontal loves. Relationship between frontal loves an behaviour. He wonders if altering the frontal lobe will effect behaviour.

40
Q

What did Egaz Moniz call his frontal lobe alteration?

A

leukotomy (leech = white tissue; tome = cutting instrument).

41
Q

How many cures, ameloriations, and no changes did Moniz claim for leukotomy?

A
  • 7 cures
  • 7 ameliorations
  • 6 no changes
42
Q

Who did Egaz Moniz practice leukotomy on? What did it involve?

A
  • Tried this technique on human subjects: individuals suffering from major depression and psychosis.
  • Rather than a full lobotomy, Moniz gave his patients leucotomies which involved cutting the white tissue with a tome or cutting instrument.
43
Q

Who are Walter Freeman and James Watts?

A
  • Walter Freeman (US neurologist)
  • James Watts (US neurosurgeon)
  • 1940s
  • Freeman-Watts Transorbital
  • Trans-orbital incision through the orbital cavity.
44
Q

Who were Freeman and Watts influenced by?

A

Moniz after he ran out of funding and was unable to continue

45
Q

How would Freeman and Watts perform their procedure?

A

Would make an incision in the eye cavity and perform the operation with a long scalpel inserted through the skull membrane and into the frontal lobe.

46
Q

When were lobotomies popular?

A

1940-1970

47
Q

How many lobotomies were approximately performed in the US in the 1940s?

A

Approximately 20 000

48
Q

Who were lobotomies used for?

A

Lobotomies were not only used for poor patients, people from all classes suffering from mental disorders became the subjects of lobotomies.

49
Q

When and why did lobotomies begin to decline?

A

With the onset of new psychotropic drugs of 1955+

50
Q

When was the era of medical experimentation without (modern) consent rules?

A

1900-1960

51
Q

What were they searching for from 1900-1960?

A

Search for a magic bullet for mental disorders.

52
Q

What was there a growth of from 1900-1960?

A

Growth of anti-psychiatry movements, sociological critiques of psychiatry, and negative popular culture portrayals of psychiatry.