lecture 1 Flashcards
non specific immunity (innate)
first line of defense
specific immunity (adaptive, acquired)
when nonspecific isn’t enough
makes unique response
humoral and CMI
innate immunity: skin
effective mechanical barrier: low pH, dry, can secrete, intact
innate immunity: complement
need to know 3 things:
what it is: set of circulating proteins in blood
role 1: opsonization (makes attractive what antibodies are bound to)
role 2: MAC (membrane attack complex recognizes things on cell wall and forms pores)
innate immunity: the rest of the components
mucous membranes, iron-binding proteins, phagocytosis
specific immunity:
humoral and CMI (cell mediated)
innate vs adaptive immunity
innate: protects against ANY invader
adaptive: protects against ONE type of invader, dependent on past exposure
humoral immunity
TH2 (activates B cells to make antibodies)
circulating antibodies
humoral immunity: antibody
protein that binds to its antigen
Igs of immuoglobulins
produced by B-cells from stimulation from antigen presenting T-cells
humoral immunity: antigen
non self
protein, glycoprotein, lipoprotein, polysaccharide
immunoglobulins (Igs/ antibodies)
distinguish self from nonself
constant region: stays similar
variable region: antigen recognition
IgG
host defense
crosses placenta and protects newborn
sugar determines shape
IgA
host defense
secretions
dimer
IgM
host defense
first antibody made, early immune response
pentamer
IgE
hypersensitivity (allergies)
defends against parasites
