LEC 17 Flashcards
what kind of lymphocyte is involved in CLL
b cells
what kind of people get CLL
older
is atypical or typical ALL more aggressive
atypical
what CD marker do CLLs aberrantly express
CD5
what CLL diagnosis has a score of more than or equal to 4
CLL
what CLL diagnosis has a score of 1-2
non Hodgkin lymphoma
what chromosome is deleted/mutated in CLL
p17 and TP53
what is the most powerful prognostic marker of CLL
IGHv
diagnosis:
- very high lymph count (could be both T and B cells)
- high WBC count
prolymphocytic leukemia
T or F: B cell prolymphoctyic leukemia has 1 prominent nucleolus
T
T or F: T cell prolymphoctyic leukemia has 1 prominent nucleolus
F
what chromosome is mutated in T prolymphocytic leukemia
inv (14)
what kind of marker is TdT
immature cells
what kind of lymphocyte is affected in hairy cell leukemia
B cell
what kind of people get infected with hairy cell leukemia
middle aged
what stain is used to diagnosis hairy cell leukemia
TRAP
what virus is associated with adult T cell leukemia/lymphoma
HTLV (human t. lymph virus)
diagnosis?
- clumped “flower” chromatin
- deeply basophilic cytoplasm
adult t. cell leukemia/lymphoma
what kind of lymph is affected in burkitt leukemia/lymphoma
b cell
what kind of burkitt leukemia/lymphoma is EBV-related, African children, extra-nodal involvement
endemic
what kind of burkitt leukemia/lymphoma is mostly abdominal, extra-nodal involvement
sporadic
what kind of burkitt leukemia/lymphoma is profound immunosuppression, blood and BM primary sites
HIV related
diagnosis:
- b lymphs are medium size, deeply basophilic cytoplasm, vacuoles “starry sky”
burkitt leukemia/lymphoma
what is the most familiar form of cutaneous T cell lymphoma
mycosis fungoides/ sezary syndrome
who does mycosis fungoides/ sezary syndrome affect
eldery
diagnosis:
- affect t cells
- cerebriform nuclei
- nucleoli not obvious
- dense chromatin
mycosis fungoides/ sezary syndrome
what organ does Hodgkin lymphoma affect
lymph nodes
what are the 2 forms of Hodgkin lymphoma
classic and lymphocyte-predominant
what form of Hodgkin lymphoma is more common
classic
who is affected by Hodgkin lymphoma
young adults
how is Hodgkin lymphoma (1st tumor) cured
combination chemotherapy.
diagnosis:
- reed-stern berg cells (bi/multinucleated)
- CD15 and CD30
hodgkin lymphoma
what kind of Hodgkin lymphoma has no reed-sternberg cells and is CD15 and CD30 neg
lymphocyte predominant
disease? malignant disorders of terminally differentiated B cells
plasma cell neoplasms
what organ do plasma cell neoplasms affect
BM
what causes multiple myeloma
monoclonal Igs
what plasma cell neoplasms have hypercalcemia, renal failure, anemia, and bone lesions
multiple myeloma
how will RBCs look with multiple myeloma
rouleux
what is the marker for multiple myeloma
CD138+
what plasma cell neoplasm has high IgM and very viscous plasma
waldenstrom’s macroglobulinemia
how is waldenstrom’s macroglobulinemia treated
plasmapheresis
what gene is mutated in waldenstrom’s macroglobulinemia
MYD88
