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LAST CLASS > LEC 17 > Flashcards

LEC 17 Flashcards

1
Q

what kind of lymphocyte is involved in CLL

A

b cells

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2
Q

what kind of people get CLL

A

older

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3
Q

is atypical or typical ALL more aggressive

A

atypical

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4
Q

what CD marker do CLLs aberrantly express

A

CD5

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5
Q

what CLL diagnosis has a score of more than or equal to 4

A

CLL

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6
Q

what CLL diagnosis has a score of 1-2

A

non Hodgkin lymphoma

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7
Q

what chromosome is deleted/mutated in CLL

A

p17 and TP53

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8
Q

what is the most powerful prognostic marker of CLL

A

IGHv

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9
Q

diagnosis:
- very high lymph count (could be both T and B cells)
- high WBC count

A

prolymphocytic leukemia

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10
Q

T or F: B cell prolymphoctyic leukemia has 1 prominent nucleolus

A

T

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11
Q

T or F: T cell prolymphoctyic leukemia has 1 prominent nucleolus

A

F

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12
Q

what chromosome is mutated in T prolymphocytic leukemia

A

inv (14)

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13
Q

what kind of marker is TdT

A

immature cells

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14
Q

what kind of lymphocyte is affected in hairy cell leukemia

A

B cell

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15
Q

what kind of people get infected with hairy cell leukemia

A

middle aged

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16
Q

what stain is used to diagnosis hairy cell leukemia

A

TRAP

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17
Q

what virus is associated with adult T cell leukemia/lymphoma

A

HTLV (human t. lymph virus)

18
Q

diagnosis?
- clumped “flower” chromatin
- deeply basophilic cytoplasm

A

adult t. cell leukemia/lymphoma

19
Q

what kind of lymph is affected in burkitt leukemia/lymphoma

A

b cell

20
Q

what kind of burkitt leukemia/lymphoma is EBV-related, African children, extra-nodal involvement

A

endemic

21
Q

what kind of burkitt leukemia/lymphoma is mostly abdominal, extra-nodal involvement

A

sporadic

22
Q

what kind of burkitt leukemia/lymphoma is profound immunosuppression, blood and BM primary sites

A

HIV related

23
Q

diagnosis:
- b lymphs are medium size, deeply basophilic cytoplasm, vacuoles “starry sky”

A

burkitt leukemia/lymphoma

24
Q

what is the most familiar form of cutaneous T cell lymphoma

A

mycosis fungoides/ sezary syndrome

25
Q

who does mycosis fungoides/ sezary syndrome affect

A

eldery

26
Q

diagnosis:
- affect t cells
- cerebriform nuclei
- nucleoli not obvious
- dense chromatin

A

mycosis fungoides/ sezary syndrome

27
Q

what organ does Hodgkin lymphoma affect

A

lymph nodes

28
Q

what are the 2 forms of Hodgkin lymphoma

A

classic and lymphocyte-predominant

29
Q

what form of Hodgkin lymphoma is more common

A

classic

30
Q

who is affected by Hodgkin lymphoma

A

young adults

31
Q

how is Hodgkin lymphoma (1st tumor) cured

A

combination chemotherapy.

32
Q

diagnosis:
- reed-stern berg cells (bi/multinucleated)
- CD15 and CD30

A

hodgkin lymphoma

33
Q

what kind of Hodgkin lymphoma has no reed-sternberg cells and is CD15 and CD30 neg

A

lymphocyte predominant

34
Q

disease? malignant disorders of terminally differentiated B cells

A

plasma cell neoplasms

35
Q

what organ do plasma cell neoplasms affect

A

BM

36
Q

what causes multiple myeloma

A

monoclonal Igs

37
Q

what plasma cell neoplasms have hypercalcemia, renal failure, anemia, and bone lesions

A

multiple myeloma

38
Q

how will RBCs look with multiple myeloma

A

rouleux

39
Q

what is the marker for multiple myeloma

A

CD138+

40
Q

what plasma cell neoplasm has high IgM and very viscous plasma

A

waldenstrom’s macroglobulinemia

41
Q

how is waldenstrom’s macroglobulinemia treated

A

plasmapheresis

42
Q

what gene is mutated in waldenstrom’s macroglobulinemia

A

MYD88

LAST CLASS (15 decks)

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