LEC 13 Flashcards
are hematologic malignancies mostly acquired or innate
acquired
what are somatic mutations
mutations that develop after birth/zygote is made
what kind of mutations do leukemias, lymphoma, and myelodysplasia (MDS) have
somatic mutations
what organ is effected in leukemia
BM
what organs are effected in lymphomas
secondary lymphoid organs
what organ is effected in MDS
BM
where in the body do solid tumor effect
tissue
where in the body do hematologic malignancies effect
blood
what kind of genes are effected in hematologic malignancies
key genes involved in hematopoiesis
what is a leukemia predisposition syndrome
hereditable germline mutations
what leukemia has bone marrow failure
- fanconi anemia
- dykeratosis congenita
where is the mutation in li fraumeni
TP53
where is the mutation in ataxia talalgia
ATM mut
what type of classification is used for acute leukemias
FAB
what type of classification is heavily dependent on cell morphology
FAB
what type of classification is more informative and precise
WHO
what kind of gene is P53
tumor supressor gene
what kind of gene is MDM2
oncogene
def? induces cancer if over expressed than P53 can’t function
oncogenes
T(8;21)
AML
T(15;17)
PML
def? normal gene, important for cell physiology
protooncogene
what is it called when a protooncogene is mutated
oncogene
how are oncogenes inherited
autosomal dominant
how are mutated tumor suppressor genes inherited
autosomal recessive
what are the 2 type of targeted therapy for hematologic malignancies
immunotherapy and cellular therapy
what is a syngeneic hematopoietic stem cell transplantation
from someone with the same genetic structure (twins)
what is a allogeneic hematopoietic stem cell transplantation
different person
what is a autologous hematopoietic stem cell transplantation
pt’s own donation
