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LAST CLASS > LEC 11 & 12 > Flashcards

LEC 11 & 12 Flashcards

1
Q

myelopoiesis is the production of what types of WBC

A

monocytes, neutrophils, eosinophils, and basophils

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2
Q

what are the 2 types of mononuclear cells

A

monocytes and lymphocytes

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3
Q

what system do lymphocytes belong to

A

immune

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4
Q

what happens when neutrophils migrate to the tissues

A

death

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5
Q

what do you call a basophil in the tissues

A

mast cells

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6
Q

T or f: you will find mast cells in circulation

A

F

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7
Q

what WBC will increase in allergic rxns

A

basophils

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8
Q

what are the 3 types of lymphocytes

A

B, T, null

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9
Q

where do you find macrophages

A

tissues

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10
Q

what myelopoiesis pool of cells can divide

A

proliferation (mitotic) pool

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11
Q

what myelopoiesis pool of cells can’t divid

A

maturation (storage) pool

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12
Q

what myelopoiesis pool of cells is depleted in exaggerated conditions

A

proliferation (mitotic) pool

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13
Q

what myelopoiesis pool of cells is only mature cells

A

maturation (storage pool)

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14
Q

what myelopoiesis pool of cells is depleted 1st in infection

A

maturation (storage) pool

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15
Q

t or f: you can ID CFU-GEMM based on morphology

A

F

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16
Q

what type of cells are neutrophils, eosinophils, basophils, monocytes, and macrophages

A

myelocytic cell

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17
Q

what type of cells are natural killer cells, B cells, and T cells

A

lymphocytic cells

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18
Q

what are the stages of the WBC (youngest to oldest)

A
  1. myeloblast
  2. promyelocyte
  3. myelocyte
  4. metamyelocyte
  5. band
  6. polymorphonuclear leukocyte
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19
Q

what cell belongs to these cells markers: CD34, Tdt, CD117, and HLA-DR

A

myeloblast

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20
Q

what condition will show all stages of WBCs in PBS

A

chronic myelogenic leukemia

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21
Q

what WBC will respond to parasitic infections and allergies

A

eosinophils

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22
Q

what is the progenitor cells of eosinophils

A

CFU-esinophil

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23
Q

what type of granules do eosinophils have

A

specific, acidophilic

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24
Q

what are in the granules of eosinophils

A

enzymes

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25
Q

what is the normal amount of eosinophils

A

1-2%

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26
Q

what is the clinical significance of eosinophilpenia

A

none

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27
Q

t or f: eosinophils can have a segmented nucleus

A

t

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28
Q

what kind of WBC responds to inflammation

A

basophils

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29
Q

t or F: basophils’ granules are water soluble

A

T

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30
Q

what chemical is in basophils’ granules

A

histamine

31
Q

what is the progenitor cell of monoblast

A

CFU-monocyte

32
Q

what cell belongs to these cell markers: CD34 + and CD117 +

A

monoblast

33
Q

what is a main characteristic of promonocyte nucleus

A

folded

34
Q

when a monocyte goes to the tissues what is it called

A

macrophage

35
Q

what is the function of a monocyte

A

phagocytize

36
Q

t or f: macrophage are ag presenting cells

A

T

37
Q

what does it mean if you see macrophages in the PB

A

damage to the tissues

38
Q

what are the primary sites of development of lymphocytes

A

BM and thymus

39
Q

what are the secondary lymphoid organs

A

lymph nodes and spleen

40
Q

what are the stages of development of lymphocytes

A
  1. lymphoblast
  2. prolymphocyte
  3. lymphocyte
41
Q

what is a cytoplasmic difference between a lymphoblast and a myloblast

A

myloblast will have rods

42
Q

lymphocyte reference range in children younger than 1

A

60-70%

43
Q

lymphocyte reference range in children 1-4 years old

A

55%

44
Q

lymphocyte reference range in adults

A

20-40%

45
Q

b lymphocyte reference range

A

20%

46
Q

t lymphocyte reference range

A

80%

47
Q

if the CD 4 + and CD8 + ratio if off what does this indicate

A

HIV

48
Q

natural killer reference range

A

3 to 15%

49
Q

what WBC will increase in viral infections

A

lymphocytes

50
Q

what is a characteristic feature of baby lymphocyte

A

halo around the nucleus

51
Q

what is a memory cell

A

lymphocyte that has been exposed to Ag

52
Q

what is a plasma cell

A

B cell that is differentiated

53
Q

what kind of viral infection have reactive lymphocytes

A

infectious mononucleosis

54
Q

what WBC is effected in pelger Huet anomaly

A

neutrophils

55
Q

what gene will be mutated in pelger Huet anomaly

A

lamin B receptor gene

56
Q

how is pelger Huet anomaly inherited

A

dominantly

57
Q

T or F: neutrophils in pelger Huet anomaly will not function normally

A

F

58
Q

how many segments will a homozygous pelger Huet anomaly pt have

A

1

59
Q

how many segments will a heterozygous pelger Huet anomaly pt have

A

2

60
Q

hereditary hyper segmentation of neutrophils is often confused with

A

megaloblastic anemia

61
Q

what is the problem with gaucher and niemann-pick disease

A

def in enzyme that breaks down neutropolysaccrides

62
Q

what enzyme is def in gaucher disease

A

beta-glucocerebrosidase

63
Q

what enzyme is def in niemann-pick disease

A

acid sphingomyelinase

64
Q

what cell is effected in gaucher and niemann-pick disease

A

macrophages

65
Q

how is alder reily anomaly inherited

A

autosomal recessive

66
Q

what is the problem with alder reilly anomaly

A

defect in mucopolysaccharides

67
Q

how will the mucopolysaccharides look in alder Reilly anomaly

A

large purple staining inclusions

68
Q

what cells are effected in chediak-higashi syndrome

A
  • granulocytes
  • monocytes
  • lymphocytes
69
Q

T or F: WBC can not function in chediak-higashi syndrome

A

T

70
Q

pt with chediak-higashi syndrome are at a high risk of what

A

infection

71
Q

what kind of disorder is may hagglin anolmaly

A

plt disorder

72
Q

what will a may hagglin anomaly PBS look like

A
  • large plt/thrombocytopenia
  • dohle- like bodies in neutrophils
73
Q

what is a common cytoplasmic finding in bacterial infections

A

toxic granulations

74
Q

def? blue inclusion

A

dohle bodies

LAST CLASS (15 decks)

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