LEC 11 & 12 Flashcards
myelopoiesis is the production of what types of WBC
monocytes, neutrophils, eosinophils, and basophils
what are the 2 types of mononuclear cells
monocytes and lymphocytes
what system do lymphocytes belong to
immune
what happens when neutrophils migrate to the tissues
death
what do you call a basophil in the tissues
mast cells
T or f: you will find mast cells in circulation
F
what WBC will increase in allergic rxns
basophils
what are the 3 types of lymphocytes
B, T, null
where do you find macrophages
tissues
what myelopoiesis pool of cells can divide
proliferation (mitotic) pool
what myelopoiesis pool of cells can’t divid
maturation (storage) pool
what myelopoiesis pool of cells is depleted in exaggerated conditions
proliferation (mitotic) pool
what myelopoiesis pool of cells is only mature cells
maturation (storage pool)
what myelopoiesis pool of cells is depleted 1st in infection
maturation (storage) pool
t or f: you can ID CFU-GEMM based on morphology
F
what type of cells are neutrophils, eosinophils, basophils, monocytes, and macrophages
myelocytic cell
what type of cells are natural killer cells, B cells, and T cells
lymphocytic cells
what are the stages of the WBC (youngest to oldest)
- myeloblast
- promyelocyte
- myelocyte
- metamyelocyte
- band
- polymorphonuclear leukocyte
what cell belongs to these cells markers: CD34, Tdt, CD117, and HLA-DR
myeloblast
what condition will show all stages of WBCs in PBS
chronic myelogenic leukemia
what WBC will respond to parasitic infections and allergies
eosinophils
what is the progenitor cells of eosinophils
CFU-esinophil
what type of granules do eosinophils have
specific, acidophilic
what are in the granules of eosinophils
enzymes
what is the normal amount of eosinophils
1-2%
what is the clinical significance of eosinophilpenia
none
t or f: eosinophils can have a segmented nucleus
t
what kind of WBC responds to inflammation
basophils
t or F: basophils’ granules are water soluble
T
what chemical is in basophils’ granules
histamine
what is the progenitor cell of monoblast
CFU-monocyte
what cell belongs to these cell markers: CD34 + and CD117 +
monoblast
what is a main characteristic of promonocyte nucleus
folded
when a monocyte goes to the tissues what is it called
macrophage
what is the function of a monocyte
phagocytize
t or f: macrophage are ag presenting cells
T
what does it mean if you see macrophages in the PB
damage to the tissues
what are the primary sites of development of lymphocytes
BM and thymus
what are the secondary lymphoid organs
lymph nodes and spleen
what are the stages of development of lymphocytes
- lymphoblast
- prolymphocyte
- lymphocyte
what is a cytoplasmic difference between a lymphoblast and a myloblast
myloblast will have rods
lymphocyte reference range in children younger than 1
60-70%
lymphocyte reference range in children 1-4 years old
55%
lymphocyte reference range in adults
20-40%
b lymphocyte reference range
20%
t lymphocyte reference range
80%
if the CD 4 + and CD8 + ratio if off what does this indicate
HIV
natural killer reference range
3 to 15%
what WBC will increase in viral infections
lymphocytes
what is a characteristic feature of baby lymphocyte
halo around the nucleus
what is a memory cell
lymphocyte that has been exposed to Ag
what is a plasma cell
B cell that is differentiated
what kind of viral infection have reactive lymphocytes
infectious mononucleosis
what WBC is effected in pelger Huet anomaly
neutrophils
what gene will be mutated in pelger Huet anomaly
lamin B receptor gene
how is pelger Huet anomaly inherited
dominantly
T or F: neutrophils in pelger Huet anomaly will not function normally
F
how many segments will a homozygous pelger Huet anomaly pt have
1
how many segments will a heterozygous pelger Huet anomaly pt have
2
hereditary hyper segmentation of neutrophils is often confused with
megaloblastic anemia
what is the problem with gaucher and niemann-pick disease
def in enzyme that breaks down neutropolysaccrides
what enzyme is def in gaucher disease
beta-glucocerebrosidase
what enzyme is def in niemann-pick disease
acid sphingomyelinase
what cell is effected in gaucher and niemann-pick disease
macrophages
how is alder reily anomaly inherited
autosomal recessive
what is the problem with alder reilly anomaly
defect in mucopolysaccharides
how will the mucopolysaccharides look in alder Reilly anomaly
large purple staining inclusions
what cells are effected in chediak-higashi syndrome
- granulocytes
- monocytes
- lymphocytes
T or F: WBC can not function in chediak-higashi syndrome
T
pt with chediak-higashi syndrome are at a high risk of what
infection
what kind of disorder is may hagglin anolmaly
plt disorder
what will a may hagglin anomaly PBS look like
- large plt/thrombocytopenia
- dohle- like bodies in neutrophils
what is a common cytoplasmic finding in bacterial infections
toxic granulations
def? blue inclusion
dohle bodies
