LAMS 6+7 Flashcards
Which of the following is a common cause of renal disease in children, and needs to be considered
during your paediatric rotation?
Diabetic glomerulosclerosis Membranous GN Focal and Segmental GN Minimal change glomerulonephritis Goodpastures syndrome
Minimal change glomerulonephritis
Which drug is useful in an acute attack of gout?
Colchicine
Which of the following syndromes does not put you at risk of a phaeochromocytoma?
VHL NF1 MEN1 MEN2 MEN3
MEN1
Which of these drugs can be used in the treatment of BPH?
5 Alpha reductase inhibitor Oestradiol Phosphodiesterase inhibitor Beta blockers Testosterone
5 alpha reductase inhibitor
Which of these is gram positive:
E-coli Haemophilus influenza Listeria monocytogenes Salmonella typhi Neisseria Meningitidis
Listeria Monocytogenes
A patient has been on Allopurinol 300 mg daily for several months and is well. Which drug should be avoided and is known to cause dangerous toxicity if taken with allopurinol
Azathioprine
A patient has a large dose of paracetamol and develops liver dysfunction. Which is the most sensitive
marker of liver damage?
Prothrombin time
A 53 year old European male presents with a recent history of weight loss and sudden onset of
abdominal pain and fever. On examination the abdomen is distended with signs of peritonitis. He
undergoes emergency laparotomy and and partial resection of small bowel and associated
mesentery.
Over the next few days the following laboratory results become available:
FBC and renal profile normal
LDH 12,000u/ml (NR 50-234)
EBV IgG serology positive, HIV 1 antibody positive
The histopathology description of a mesenteric lymph node: The node is effaced and diffusely
infiltrated by large lymphoid cells. Under low poor the node has a starry sky appearance. On
immunohistochemistry the large cells are positive for CD20, surface Immunoglobulin, myc and EBER
(Ebstein Barr Virus encoded small RNAs) the cells are negative for CD3 and CD30. Ki67 expression
is 98%. Karyotype analysis reveals t(8;14)(q24;q32).
What is the most likely diagnosis?
Burkitt Lymphoma
Superoxide dismutase 1 is a misfolded protein associated with which condition?
MND
In a test for a disease, which term describes the number of true positives divided by the total number
of people that have the disease?
Sensitivity
Which of the following on cause hypercalcaemia?
Osteomalacia Paget's Sarcoidosis Secondary Hyperparathyroidism Osteoporosis
Sarcoidosis
By what mechanism does the disease in the last question cause the hypercalaemia?
Ectopic expression of 1 alpha hydroxylase
Which of the following is useful in patients with pseudomonas aeruginosa lung infection
Ceftriaxone Clarithromycin Gentamicin Metronidazole Flucloxacillin
Gentamicin
What is a chronic inflammatory bowel disease affecting the large bowel and duodenum is most likely to be?
Crohn’s disease
The severity of which of these conditions is measured by the Breslow score?
Melanoma
