Laflamme- Chapter 9 (Miscellaneous) Flashcards
What are the 6 components of the RCRI?
CAD CHF CVD IDDM Cr > 176 Intrathoracic, intraperitoneal or vascular surgery
What is high risk on RCRI?
3 or more points = high risk (9%)
What % of troponin elevation is Type 1 MI post surgery?
5%
How to reprogram pacemakers during OR? ICD?
- PPM: VOO or DOO
- ICD: Deactivate tachyarrhythmia therapies or magnet during the operation
What % of all CAD deaths can be attributed to smoking?
30%
What is benefit of CV reduction after smoking cessation?
Similar to non smokers after 5 years of smoking cessation
What do lipoproteins do?
-transport TG and cholesterol in the blood
What are chylomicrons?
Large nonatherogenic lipoproteins transporting TG from the GI tract
What is VLDL?
Large nonatherogenic lipoproteins transporting TG from the liver (apo B100)
What is LDL?
Atherogenic lipoproteins responsible for atherosclerosis, mainly contain cholesterol, apoB100
How is LDL calculated?
Total cholesterol - HDL - (0.45 x TG)
*only if TG < 4.5 mmol/L
What is HDL?
Antitherogenic properties, contains apolipoprotein AoA1
How does hypertriglyceridemia result in more LDL?
TG enriched LDL -> Formation of smaller and denser LDL due to modification by hepatic lipase -> dense, atherogenic LDL
What are 12 populations to screen for dyslipidemia?
Male > 40
Female > 50
DM
HTN
Smoking
BMI > 27
CrCL < 60
Atherosclerosis
ED
Family history of premature CAD or dyslipidemia
ED
HIV
What are 8 causes of decreased HDL?
Smoking
Obesity
Sedentary lifestyle
DM
CRF
HyperTG
Steroids
Cyclosporine
What is inheritance of FH?
-LDL R receptor mutation, AD, 1/1000
3 physical exam findings of FH?
Xanthelasmas
Senile arcus
Tendinous xanthomas
What is familial dysbetalipoproteinemia?
-Homozygote for ApoE2 (less effective binding to hepatic receptors)
Two physical exam findings of Familial Dysbetalipoproteinemia?
-Tuberous xanthomas, Palmar xanthomas
Biochemical evidence of Dysbetalipoproteinemia?
ApoB/TC ratio < 0.15
Three inherited causes of decreased HDL?
- Apo A1 deficiency
- Tangiers Disease
- Familial LCAT deficiency
What to consider Familial combined hyperlipidemia?
- Apo B > 120 mg/dl
- TG > 1.5 mmol/l
- History of premature CAD
when to start fenofibrate for hypertriglyceridemia? (2)
- TG > 10
- Pancreatitis
How do statins work?
- HMG Coa reductase inhibitor which reduces the intracellular cholesterol synthesis and increased expression of LDL receptor
- Pleotropic and antinflammatory response
Name two Bile acid sequestrants and how much do they lower LDL by
-Colestipol or Colesevalam, reduced LDL by 15-30%
How does Ezetimibe work and how much does it reduce LDL by?
- 20%
- Interferes with NPC1-L1 protein of intestinal epithelial cells
Only lipid lowering therapy that increased HDL?
-Niacin
What are 4 sideeffects of Niacin?
-Flushing, Hyperuricemia, Hyperglycemia, Gastritis
What are 7 causes for statin intolerance/myalgias?
Hypothyroidism
Renal failure
Liver disease
PMR
Steroid use
Vitamin D deficiency
Primary muscle disease
What 7 risk factors for statin myopathy?
- statin dose
- drug interactions
- > 75 years old
- Renal failure
- Liver disease
- Alcohol use
- Pre-existing myopathy
When should you be worried about statin s/e based on AST/ALT and CK?
3x, 5x
How to approach statin toxicity (ALT/AST + CK)
-DC statin, consider DDx, monitor until normalization, reintroduce at a lower dose of less potent statin (Pravastatin, Fluvastatin) or QoD dosing
What if statin s/e doesn’t meet criteria to DC based on AST/ALT or CK?
-Continue treatment and check again in 6 weeks. If stable than resume.
Three ways to diagnose HTN in the office?
- 180/110 mmhg x 1
- 160/100 mmhg x 3
- 140/90 mmhg x 5
ABPM cut offs for HTN diagnosis?
- Daytime > 135/85
- 24 hour SBP > 130/80
- Night time BP should drop by 10%
Home BP monitoring cut off?
> 135/85
Work up for renovascular disease?
-Doppler renal arteries, MRA, CTA
Work up for Primary hyperaldo?
- Increased plasma aldoserone/renin ratio
- Suppression test with salt load
- Adrenal CT scan or MRI
- Adrenal vein catheterization
Work up for Cushings?
- Urinary cortisol
- Suppression test (1mg dexamethasone)
- CT scan adrenals
Work up for Pheochromocytoma?
-Plasma metanephrines, urine meta, CT scan or MRI
Why might elderly patients have NIBP lower than arterial monitoring?
-Secondary to rigid arteries that are not compressed by the cuff
How does Metformin work? How much does it reduce Hba1c by?
- decreases hepatic glucose synthesis
- decrease by 0.8%
Sulfonylureas?
- Stimulates insulin secretion by the pancreas
- 0.7%
GLP1 agonist
- Increase insulin secretion, decreases glucagon secretion
- 1%
DPP4 inhibitors
Inhibits the breakdown of GLP1
-0.6%