Lab and Patho - Final Flashcards
The penis, vulva, vaginal canal, & clitoris are there to ultimately encourage reproduction
(CHART - No Question)
Key Structure of the Ovum
- Oocyte (DNA)
- Zona Pellucida (inner layer)
- Corona radiata (outer layer)
- Produced by oogenesis in the ovaries
- Maturation begins & pauses while in the womb; reactivates at puberty
Key Structure of Sperm
- Acrosome
- Head (DNA)
- Tail (Flagella)
- Produced by spermatogenesis in
the seminiferous tubules (testes) - Continuously produced by dividing
stem cells in testes
The function of the Ovaries
storage and maturation of oocytes
and reproductive hormones
Where is estrogen produced?
Follicular cells
How is progesterone produced?
After ovulation, the follicle ruptures & becomes the corpus luteum and produces progesterone
What structures function is to sweep the ovum into uterine tubes after ovulation?
Fimbriae
Where is the site of conception?
Uterine tubes
What is the function of the cervix?
To keep bacteria from
entering the uterus
What structures function is the production of sperm and reproductive hormones?
Testes
Epididymis function is…
the site of sperm mobilization
What structure has the function to store sperm and initiate the ejaculation process?
Vas Deferens
What the key function of the mammary glands?
Lactation
What lab tests are associated with pregnancy?
hCG, CBC, Blood Typing, Urinalysis, Urine Culture
Infectious Disease Testing (Syphilis, HIV, Hepatitis etc..)
Carrier & Genetic Screening
Glucose/Diabetes Screening (OGTT)
Group B Strep Screening
What is an Ectopic Pregnancy?
Conception happens outside the endometrium
What condition is life threatening resulting in Hemolysis, Elevated Liver enzymes, & Low Platelets?
HELLP Syndrome
What are the key urinary system structures?
- Kidneys
- Ureter
- Urinary Bladder
- Urethra
These functions are a part of what system;
Regulation of blood volume, blood pressure, & hydration
Homeostasis of blood pH & maintenance of acid-base balance
Filtration & conservation of blood products, nutrients, & metabolic waste
Electrolyte balance
Regulation of RBC production through production of `erythropoietin
Urinary System
Key Functions of the Kidney
Filtration of blood: from renal artery & through the glomerular capillaries
Urine production: nephrons control absorption and secretion of water, electrolytes, bicarbonate/hydrogen, & wastes
Production of Renin & Erythropoietin
How are kidneys involved in acid-base balance?
What is urine made up of?
About 95% water and 5% waste products
Urine production involves excretion and elimination of;
Ammonia - byproduct of breakdown of nitrogen containing
molecules (amino acids)
Creatinine - from muscle metabolism
Uric acid - breakdown & recycling of RNA
Hydrogen - byproduct of cellular metabolism
What disorder is an infection, usually bacteria, of urinary tract including urethra, bladder (cystitis), or kidney (pyelonephritis)?
UTI (Urinary Tract Infection)
What are kidney stones?
Hard deposits made of minerals & salts that form inside your kidneys, can get lodged inside the ureter
What are the key structures of the Lymphatic System?
Lymph
Lymph Vessels & Ducts
Lymphoid Organs
Thymus
Spleen
Bone Marrow
Lymph Nodes
Lymphoid Nodules
Name 1 function of the Lymphatic System.
Lymphocytes - Production, maintenance, & distribution
One way return of fluid and solutes from peripheral tissues to bloodstream; aids in distribution of hormones, nutrients, & wastes from tissues –> circulation.
Provide recognition, resistance & immunity to “debris”
What is Lymph similar to?
Blood plasma
but with a lower concentration of proteins
What two ducts does the lymphatic vessels direct lymph towards?
- Right Lymphatic Duct
- Thoracic Duct
What are the Primary Lymphoid Organs?
^ Bone Marrow - production of WBC, Site of maturation B lymphocytes
^ Thymus - Site of T Lymphocyte maturation
^ Lymph Nodes - filter debris & pathogen, site of adaptive immune responses
^ Spleen - Mechanical and Biological filtration of blood
^ Lymphoid Nodules - Filter incoming pathogens & debris (inhalation/ingestion)
Tonsillitis is?
Chronic inflammation of the tonsils
What is the inability of lymph vessels to return lymph to circulation due to obstruction or vessel disruption?
Lymphedema
What is the immune systems function?
to attacks irritants, abnormal substances, microorganism, &
other foreign substances
Adaptive immunity is and what cells are involved?
Acquired immunity
Lymphocytes (B & T cells)
Innate Immunity involves what cells?
Native immunity or Genetic immunity
Phagocytic
- macrophages, neutrophils, dendritic cells
Compare Innate and Adaptive Immunity
An allergic reaction is?
The immunes system hypersensitivity response to
specific antigens
What disorder do the autoantibodies target synovial membranes triggering chronic inflammation?
Rheumatoid Arthritis
Study the tests and what structure they are associated with in the body.
Specialty tests and why they are special
What is the difference between MCV, MCHC, MCH?
MCV = average size of RBC
MCH = amount of hemoglobin in 1 RBC
MCHC = average weight of hemoglobin in one liter
Platelet clumping is a cause of…
poor mixing
What does -penia mean?
low
What does -cytosis mean
high
What tests are associated with Sepsis?
PCT
LDH
Lactate
Glucose Studies include what tests?
- Glucose
a. Random
b. Fasting - Hemoglobin A1C
- Glucose Tolerance Testing
What tests are done with a Complete Blood Count?
WBC+Diff
RBC
PLT
HGB
HCT
MCV
MCH
MCHC
RDW
Iron Study tests include…
- Iron + TIBC (Total Iron Binding Capacity)/Transferrin
(Transport) - Ferritin (storage)
- Hemoglobin (active storage)
Transfusions include what tests?
Group & Screen
XMatch
RHIG eligibility
Electrolyte tests include…
- Sodium (Na+)
- Potassium (K+)
- Chloride (Cl-)
- Bicarbonate (HCO3-)
Mineral Testing/Extended
Electrolytes
1. Calcium (Ca)
2. Phosphorous (PO4)
3. Magnesium (Mg)
Tests associated with inflammation are
- CRP (ESR in heme)
- Procalcitonin (PCT) (Bacterial)
ESR
Serum Toxicology tests are
ETOH (Ethanol - CNS depression)
ACET (Acetaminophen - liver toxicity)
SALI (Salicylates - decreased platelet aggregation)
Tests associated with Urine Toxicology
a. Fentanyl (FENT)
b. Oxycodone (Oxy)
c. Morphine (MOP)
d. Marijuana (THC)
e. Methamphetamines
f. Amphetamines (AMP)
g. Benzodiazepines (BENZO)
h. Cocaine
i. Methadone
j. Opiates
k. PCP
l. GHB
m. Barbiturates (Barb)
Volatiles tests are
methanol
isopropanol
acetone
ethylene glycol
Coagulation tests are
PT/INR
PTT
FIB
D-Dimer
Tests associated with Tumor Marker are
CA19-9 (Pancreatic Cancer)
CA125 (Ovarian Cancer)
CA15-3 (Breast Cancer)
CEA (Colorectal Cancer)
AFPS (Testicular, Ovarian, Stomach Cancer)
Liver associated tests
TBILI
ALP
ALT
AST
TP
GGT
ALB
Cardiac tests
- Troponin (Acute MI)
- BNP (Congestive Heart Failure)
- LDH
- CK (MB)
AST
Lipids
Test associated with the Kidney
CREA (EGFR)
ALB
UREA (BUN)
Therapeutic Drug Monitoring tests include
- Antibiotics
a. Gentamycin
b. Tobramycin
c. Amikacin
d. Vancomycin - Anti-Epileptic
a. Phenytoin
b. Phenobarbital
c. Carbamazepine
d. Valproic Acid - Cardioactive
a. Digoxin - Mood Stabilizer
a. Lithium - Immunosuppressants
a. Cyclosporin - Bronchodilators
a. Theophylline
Lipid panels include
- Cholesterol
a. HDL
b. LDL - Triglycerides
- *Lipoprotein Electrophoresis
Tests for pancreatic function include
- Lipase
- Amylase
Tests for the bone are
- Calcium
- Phosphorous
- ALP
What tests are associated with Hormone Testing?
- Thyroid: TSH, T3, T4
- Reproductive: HCG, LH, FSH, TEST, EST, PRL
- Adrenals: CORT (AM, PM, or RDM)
Lipid Panel consists of… (3)
- Cholesterol
a. HDL
b. LDL - Triglycerides
- *Lipoprotein Electrolytes EDTA
Trace Metals
Copper (Cu)
Zinc (Zn)
What is an Antibody?
A protein developed in response to antigen
Agglutination is…
Clumping of antibody and antigens
Antigen is?
protein that acts as an identifier
What is a Transfusion Reaction?
When the patient’s immune system reacts with blood transfused
What is Blood Products?
Medication made from blood components
What is the fixative in Histology?
What is the ratio used to mix (fix:spec)?
Formaldehyde
20:1
What is the fixative used in Cytology?
What is the ratio used (fix:spec)?
Ethanol
1:1
What test tubes can be centrifuged within 4 minutes of collection?
Sodium Citrate
EDTA - Ammonia
PST
Dark Green (Lith. Hep.)
What tubes need to be placed on ice immediately?
Ammonia
Lactate
Capillary Blood Gases
What lives in the bloodstream for 2-3 days and then moves into tissue, as a macrophage?
Monocytes
What WBC is the 1st on site, used with bacterial infections and phagocytosis?
Neutrophils
The WBC that is associated with allergies and neoplastic disorders, is
Basophils
What WBC is used with allergies and parasites?
Eosinophil
What WBC is used when there is a viral infection and consists of T Cells (Cell-Mediated Destruction) and B Cells (Antibody Production)
Lymphocytes
Who are the cells that are first on the scene of an injury with a lifespan of 8-12 days?
Thrombocytes
What blood component is associated with the final stage of clot formation (clot solidification)?
Fibrinogen
What blood component is associated with osmotic pressure maintenance and molecule binding for transport?
Albumin
What blood component is associated with immune response?
Leukocytes
What blood component is molecule binding for transport and used in antibody production?
Globulin
What blood component is associated with the clot breakdown?
Plasmin
What blood component is in the initial clotting stages (plugging of vessel)?
Platelet
What blood component is associated with gas transportation and Bicarbonate CO2 conversion?
Erythrocyte
Which WBC’s are Granulocytes?
Neutrophils
Basophils
Eosinophils
What WBC’s are Arangulytes?
Monocytes
Lymphocytes