L14 Adaptive Immunity UF

Question 1

Key features of innate immunity

Answer 1

Limited specificity
Found in all tissues especially at barrier sites
Acts quickly following infection
Limited memory

Question 2

Key features of adaptive immunity

Answer 2

Specific for particular proteins/ antigens
Mainly found in lymphoid organs
Takes 5-10 days to get going
Long lived immune memory

Question 3

Types of adaptive immune cells and what do they do

Answer 3

B and T cells
Cells that specifically recognise antigens viaspecialised surface receptors

Question 4

What do B cells receptors bind to

Answer 4

native proteins/ antigens
(no accessory cells required)

Question 5

What do T cells recognise

Answer 5

Processed antigen presented on MHC molecules on the surface of antigen presenting cells
CD4 T cells see longer peptides in MHC class 2 molecules
CD8 T cells see short peptides in MHC class 1 molecules

Question 6

Where are adaptive immune cells generated and activated

Answer 6

Generation: primary lymphoid organs (thymus and bone marrow)
Activation: secondary lymphoid organs (lymph nodes and spleen)

Question 7

Steps in adaptive immune response

Answer 7

T cell activation
T cell differentiation
T cell effector stage

Question 8

What do the types of adaptive immune cells do

Answer 8

CD4+ T cell - coordinate immune response
CD8+ T cell - kill infected cells
B cells - make antibody to clear up pathogen

Question 9

What types of Antibodies are there

Answer 9

IgM, IgG, IgE, IgA