Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

[MT 6314] - 1st Shifting > Kinetics 1-3 > Flashcards

Kinetics 1-3 Flashcards

1
Q

the measure of the
apparent space in the body available to
contain the drug

A

Volume of distribution:

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

the measure of the ability of the
body to eliminate the drug

A

Clearance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

dose-concentration

A

pharmacokinetic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

concentration-effect

A

pharmacodynamic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

3 KINETIC HOMOGENEITY

A

Rate of input (absorption)
Rate of distribution to other tissues
Rate of elimination

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

is the function of three
pharmacokinetic rates

A

Plasma concentration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

represents the absorption whether it
is administered on any route

A

Rate of Input

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

to the peripheral
tissues of target organs

A

Rate of distribution to other tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

which is the function of the
metabolizing organs (liver) which is excretory and
so is your kidneys.

A

Rate of elimination

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

water-soluble drug is
excreted through the _____.

A

Urine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

. Lipid-soluble drug, since
it is insoluble in water is excreted via the______.

A

the bile (biliary
excretion).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

DISTRIBUTION: Deliver to interstitial and intracellular fluids. Initial organ are _____

A

Liver, Kidney, Brain (Slower in muscle, viscera, fat and skin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

PLASMA BINDING PROTEINS: Acidic drugs binds to ______

A

Albumin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

PLASMA BINDING PROTEINS: Basic drugs binds to ______

A

alpha 1 acid glycoprotein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

T/F: More highly protein bound drug will displace the
less protein bound drug

○ Eg, A- 90% protein bound
○ B- 50% protein bound
○ A will displace B
○ More unbound drug “B” to act on the
receptor site

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

When plasma proteins are lower
than normal, total drug concentrations will be ______higher or lower

but unbound concentrations will not be affected.

A

Lower

17
Q

assumed the patient is obese,
drugs do not readily penetrate fat (e.g ______)

A

Gentamicin, Digoxin, Tacrolimus, Gemcitabine

18
Q

T/F: EFFECTIVE DRUG CONCENTRATION - Unique for a particular drug in a particular
patient

We based this on the normal or the average that is
seen on a population

A

True

19
Q

2 important parameters (known absorption):

A

○ 1. VOLUME OF DISTRIBUTION (Vd)
○ 2. CLEARANCE (CL)

20
Q

relates the amount of drug in the body to the concentration of drug in blood or plasma:

A

Volume of distribution (V)

21
Q

Formula of Volume of distribution (V)

A

V = Amount of drug in body / C

22
Q

volume of distribution may be defined with
respect to ____, ____, _____ (unbound drug), depending on the concentration used in the
equation above C = Cb, Cp, or Cc

A

blood, plasma, or water

23
Q

high volumes of distribution have ____ conc. in extravascular tissue than in the vascular compartment

ie, they are not homogeneously distributed

A

higher

24
Q

Drugs that are completely retained within the
vascular compartment, would have a _______ (minimum/maximum) possible volume of distribution equal to the plasma component in which they are distributed

A

minimum

25
Q

Physical volumes of some body compartments

Compartment: Total body water r (0.6 L/kg1)

A

Small water-soluble molecules: eg, ethanol

26
Q

Physical volumes of some body compartments

Compartment: Extracellular water r (0.2 L/kg)

A

Large water-soluble molecules: eg, gentamicin

27
Q

Physical volumes of some body compartments

Compartment: Plasma (0.04 L/kg)

A

large protein molecules: eg,
antibodies

28
Q

Physical volumes of some body compartments

Compartment: Bone (0.07 L/kg)

A

certain ions: eg, lead;
fluoride

28
Q

Physical volumes of some body compartments

Compartment: Fat (0.2 - 0.35 L/kg)

A

highly lipid-soluble
molecules: eg, diazepam

29
Q

ANother formula for Volume of distributioon

A

Vd = amount of drug in the body/plasma drug conc.

30
Q

Unit for Vd

A

Liters or Vd/kg

31
Q

apparent space in the body available to
contain the drug

A

Volume of Distribution

32
Q

t/f: our body is a compartment of water, divided by the
lipid barriers

70 kilograms is the average. So, our body is about 70
- 80% water, depending on our muscularity

A

True

33
Q

More Muscular, ____ (less/more) water

A

More

34
Q

More adipose tissue, _____(more/less) fluid percentage)

A

less

[MT 6314] - 1st Shifting (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions