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[MT 6314] - 1st Shifting > Intro 5 - 7.5 > Flashcards

Intro 5 - 7.5 Flashcards

1
Q

PHARMACODYNAMICS:’

May produce same physiologic effect as
agonist-induced activity

  • Constitutive activity
  • Agonist-binds to and activate the receptor
A

Constitutive activity

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2
Q

PHARMACODYNAMICS:’

○ Occurs in the absence of the agonist
○ Even without any simulation, the receptors will execute their function

  • Constitutive activity
  • Agonist-binds to and activate the receptor
A

Constitutive activity

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3
Q

PHARMACODYNAMICS:’

Full agonist
Partial agonist
Allosteric modulators
Drugshape
Allosteric Activator
Allosteric inhibitor
Inverse agonist

  • Constitutive activity
  • Agonist-binds to and activate the receptor
A

Agonist-binds to and activate the receptor

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4
Q

PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor

Activates receptor-effector system to the maximum extent (Ra-D pool){activated form}

  • Full agonist
  • Partial agonist
  • Allosteric modulators
  • Drugshape
  • Allosteric Activator
  • Allosteric inhibitor
    Inverse agonist
A

Full agonist

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5
Q

PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor

Drugs that can activate their receptor-effector systems to the maximum extent when they are administered at concentrations that saturate the receptor pool

  • Full agonist
  • Partial agonist
  • Allosteric modulators
  • Drugshape
  • Allosteric Activator
  • Allosteric inhibitor
    Inverse agonist
A

Full agonist

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6
Q

PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor

Can activate to the full extent. eg: heart rate and epinephrine (its endogenous agonist)

  • Full agonist
  • Partial agonist
  • Allosteric modulators
  • Drugshape
  • Allosteric Activator
  • Allosteric inhibitor
    Inverse agonist
A

Full agonist

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7
Q

PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor

Binds to the same receptors and activate them in the same way but do not evoke as great a response

  • Full agonist
  • Partial agonist
  • Allosteric modulators
  • Drugshape
  • Allosteric Activator
  • Allosteric inhibitor
    Inverse agonist
A

Partial Agonist

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8
Q

PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor

NO response no matter how high the concentration is

  • Full agonist
  • Partial agonist
  • Allosteric modulators
  • Drugshape
  • Allosteric Activator
  • Allosteric inhibitor
  • Inverse agonist
A

Partial Agonist

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9
Q

PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor

These drugs have low intrinsic efficacy

  • Full agonist
  • Partial agonist
  • Allosteric modulators
  • Drugshape
  • Allosteric Activator
  • Allosteric inhibitor
  • Inverse agonist
  • Antagonist
A

Partial Agonist

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10
Q

PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor

Binds to a site on the receptor molecule separate from the agonist binding site

  • Full agonist
  • Partial agonist
  • Allosteric modulators
  • Drugshape
  • Allosteric Activator
  • Allosteric inhibitor
  • Inverse agonist
  • Antagonist
A

Allosteric modulators

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11
Q

PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor

Modifies receptor activity without blocking
agonist activity

  • Full agonist
  • Partial agonist
  • Allosteric modulators
  • Drugshape
  • Allosteric Activator
  • Allosteric inhibitor
  • Inverse agonist
  • Antagonist
A

Allosteric modulators

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12
Q

PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor

May increase or decrease response to
agonist. Noncompetitive

  • Full agonist
  • Partial agonist
  • Allosteric modulators
  • Drugshape
  • Allosteric Activator
  • Allosteric inhibitor
  • Inverse agonist
  • Antagonist
A

Allosteric modulators

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13
Q

PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor

Lock and Key mechanism

  • Full agonist
  • Partial agonist
  • Allosteric modulators
  • Drugshape
  • Allosteric Activator
  • Allosteric inhibitor
  • Inverse agonist
  • Antagonist
A

Drug shape

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14
Q

PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor

● Enzymes are a class of receptors
● There is a class of drugs called allosteric modulators, which means they could bind together with the agonist

  • Full agonist
  • Partial agonist
  • Allosteric modulators
  • Drugshape
  • Allosteric Activator
  • Allosteric inhibitor
  • Inverse agonist
  • Antagonist
A
  • Drugshape
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15
Q

PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor

When paired with partial agonists, it may
reach the full response

  • Full agonist
  • Partial agonist
  • Allosteric modulators
  • Drugshape
  • Allosteric Activator
  • Allosteric inhibitor
  • Inverse agonist
  • Antagonist
A

Allosteric Activator

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16
Q

PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor

When paired with full agonists, it may not
reach the full response

  • Full agonist
  • Partial agonist
  • Allosteric modulators
  • Drugshape
  • Allosteric Activator
  • Allosteric inhibitor
  • Inverse agonist
  • Antagonist
A

Allosteric inhibitor

17
Q

PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor

○ Drug has a stronger affinity for the Ri pool (nonfunctional form)
○ Reduces constitutive activity
○ Results in effects that are opposite of the effects produced by conventional agonists

  • Full agonist
  • Partial agonist
  • Allosteric modulators
  • Drugshape
  • Allosteric Activator
  • Allosteric inhibitor
  • Inverse agonist
  • Antagonist
A

Inverse agonist

18
Q

PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor

Binds to a receptor, compete with and prevent binding by other molecules. Like beta blockers for hypertension

  • Full agonist
  • Partial agonist
  • Allosteric modulators
  • Drugshape
  • Allosteric Activator
  • Allosteric inhibitor
  • Inverse agonist
  • Antagonist
A

Antagonist

19
Q

What type of molecule is this:

Binds to receptor and activates it leading to biological response

  • agonist
  • antagonist
A

agonist

20
Q

What type of molecule is this:

Mimic the action of endogenous ligands

  • agonist
  • antagonist
A

agonist

21
Q

What type of molecule is this:
Binds to receptor but does not activate it

  • agonist
  • antagonist
A

antagonist

22
Q

What type of molecule is this:

Block the receptor from being activated by agonist

  • agonist
  • antagonist
A

Antagonist

[MT 6314] - 1st Shifting (23 decks)

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