Intro 5 - 7.5 Flashcards
PHARMACODYNAMICS:’
May produce same physiologic effect as
agonist-induced activity
- Constitutive activity
- Agonist-binds to and activate the receptor
Constitutive activity
PHARMACODYNAMICS:’
○ Occurs in the absence of the agonist
○ Even without any simulation, the receptors will execute their function
- Constitutive activity
- Agonist-binds to and activate the receptor
Constitutive activity
PHARMACODYNAMICS:’
Full agonist
Partial agonist
Allosteric modulators
Drugshape
Allosteric Activator
Allosteric inhibitor
Inverse agonist
- Constitutive activity
- Agonist-binds to and activate the receptor
Agonist-binds to and activate the receptor
PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor
Activates receptor-effector system to the maximum extent (Ra-D pool){activated form}
- Full agonist
- Partial agonist
- Allosteric modulators
- Drugshape
- Allosteric Activator
- Allosteric inhibitor
Inverse agonist
Full agonist
PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor
Drugs that can activate their receptor-effector systems to the maximum extent when they are administered at concentrations that saturate the receptor pool
- Full agonist
- Partial agonist
- Allosteric modulators
- Drugshape
- Allosteric Activator
- Allosteric inhibitor
Inverse agonist
Full agonist
PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor
Can activate to the full extent. eg: heart rate and epinephrine (its endogenous agonist)
- Full agonist
- Partial agonist
- Allosteric modulators
- Drugshape
- Allosteric Activator
- Allosteric inhibitor
Inverse agonist
Full agonist
PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor
Binds to the same receptors and activate them in the same way but do not evoke as great a response
- Full agonist
- Partial agonist
- Allosteric modulators
- Drugshape
- Allosteric Activator
- Allosteric inhibitor
Inverse agonist
Partial Agonist
PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor
NO response no matter how high the concentration is
- Full agonist
- Partial agonist
- Allosteric modulators
- Drugshape
- Allosteric Activator
- Allosteric inhibitor
- Inverse agonist
Partial Agonist
PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor
These drugs have low intrinsic efficacy
- Full agonist
- Partial agonist
- Allosteric modulators
- Drugshape
- Allosteric Activator
- Allosteric inhibitor
- Inverse agonist
- Antagonist
Partial Agonist
PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor
Binds to a site on the receptor molecule separate from the agonist binding site
- Full agonist
- Partial agonist
- Allosteric modulators
- Drugshape
- Allosteric Activator
- Allosteric inhibitor
- Inverse agonist
- Antagonist
Allosteric modulators
PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor
Modifies receptor activity without blocking
agonist activity
- Full agonist
- Partial agonist
- Allosteric modulators
- Drugshape
- Allosteric Activator
- Allosteric inhibitor
- Inverse agonist
- Antagonist
Allosteric modulators
PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor
May increase or decrease response to
agonist. Noncompetitive
- Full agonist
- Partial agonist
- Allosteric modulators
- Drugshape
- Allosteric Activator
- Allosteric inhibitor
- Inverse agonist
- Antagonist
Allosteric modulators
PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor
Lock and Key mechanism
- Full agonist
- Partial agonist
- Allosteric modulators
- Drugshape
- Allosteric Activator
- Allosteric inhibitor
- Inverse agonist
- Antagonist
Drug shape
PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor
● Enzymes are a class of receptors
● There is a class of drugs called allosteric modulators, which means they could bind together with the agonist
- Full agonist
- Partial agonist
- Allosteric modulators
- Drugshape
- Allosteric Activator
- Allosteric inhibitor
- Inverse agonist
- Antagonist
- Drugshape
PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor
When paired with partial agonists, it may
reach the full response
- Full agonist
- Partial agonist
- Allosteric modulators
- Drugshape
- Allosteric Activator
- Allosteric inhibitor
- Inverse agonist
- Antagonist
Allosteric Activator
PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor
When paired with full agonists, it may not
reach the full response
- Full agonist
- Partial agonist
- Allosteric modulators
- Drugshape
- Allosteric Activator
- Allosteric inhibitor
- Inverse agonist
- Antagonist
Allosteric inhibitor
PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor
○ Drug has a stronger affinity for the Ri pool (nonfunctional form)
○ Reduces constitutive activity
○ Results in effects that are opposite of the effects produced by conventional agonists
- Full agonist
- Partial agonist
- Allosteric modulators
- Drugshape
- Allosteric Activator
- Allosteric inhibitor
- Inverse agonist
- Antagonist
Inverse agonist
PHARMACODYNAMICS:’ Agonist-binds to and activate the receptor
Binds to a receptor, compete with and prevent binding by other molecules. Like beta blockers for hypertension
- Full agonist
- Partial agonist
- Allosteric modulators
- Drugshape
- Allosteric Activator
- Allosteric inhibitor
- Inverse agonist
- Antagonist
Antagonist
What type of molecule is this:
Binds to receptor and activates it leading to biological response
- agonist
- antagonist
agonist
What type of molecule is this:
Mimic the action of endogenous ligands
- agonist
- antagonist
agonist
What type of molecule is this:
Binds to receptor but does not activate it
- agonist
- antagonist
antagonist
What type of molecule is this:
Block the receptor from being activated by agonist
- agonist
- antagonist
Antagonist
