Kidney cancer

Question 1

3 types of kidney cancers

Answer 1

1. Clear cell carcinoma
2. Papillary renal cell carcinoma
3. Chromophobe renal carcinoma

Question 2

Clear cell carcinoma

Answer 2

1. Originates from epithelial cells of proximal convulated tubule
2. Chromosome 2 VHL gene tumor supressor mutation - Von Lindau hippel disease - causes benign cysts and tumors to form
3. Can invade renal vein and spread
4. yellow-orange -gray

Question 3

Papillary renal carcinoma

Answer 3

1. Forms within kidney tubules, within proximal or distal convulated tubule
2. Hereditiary papillary renal carcinoma - MET gene mutation
3. Less vibrant yellow-orange due to lower lipid content

Question 4

Chromophobe renal carcinoma

Answer 4

1. Least common
2. Intercalated cells of collecting duct
3. Tumors have multiple losses of entire chromosomes
4. Grossly tan brown morph

Question 5

Clincial manif

Answer 5

1. Haematuria
2. Palpable abdominal mass
3. Flank pain
4. Fever/weight loss