kef 40

Question 1

ti ipodilwnoun oi mialgies kata tin anapavsi

Answer 1

flegmoni

Question 2

ti ipodilwnoun oi mialgies kata tin askisi

Answer 2

metavoliki diataraxi

Question 3

giati simvaienei i epodini miiki sispasi (krampa)

Answer 3

se diataraxi tou periferikou kinitikou nevrwna ,i logo metavolikwn diataraxwn meta apo askisi(siopili i/m grafika)

Question 4

pote exoume avksisi tis kreatinikis kinasis(ck)

Answer 4

se okseia ravdomiolisi,…flegmonwdeis,ipothireoeidiki kai farmakogeneis miopatheies, kai stis miikes distrofies,swmatiki askisis,mikros travmatismos mios,

Question 5

ti den paragete ston mi meta apo kopwsi otan exoume diataraxes glykogonolisis i glikolisis( provilma sta mitochondrial) ,dld metavoliki miopatheia

Answer 5

galaktiko oksi

Question 6

se miopatheies ti exoume sto img

Answer 6

1.se ekousia sispasi epidi meiwnete o arithmos miikwn inwn exoume afthona polifasika dinamika kinitikwn monadwn me mikri diarkeia kai xamili ipsos 2. epidi i miiki ina nekrwnete kai aponevrwnete exoume aftomati drastiriotita 3.omadopoiisi

Question 7

ti einai oi miikes distrofies

Answer 7

einai klironimikes ekfilistikes pathiseis twn skeletikwn miwn me proodeftiko xaraktira

Question 8

ti einai i nosos Duchenne kai i nosos Becker

Answer 8

einai filosindetes(kakoithis sto xr x kai kaloithis) miikes distrofies(distrofinopatheies) ,me pathogeneia tis distrofinis mias prwteinis tou sarkeilimmatos(distrofinopatheies)

Question 9

kliniki eikona Duchenne(kakoithis filosindeti miiki distrofia)

Answer 9

ekdilwsi 2-5 etos zois,diskolia stin kinisi,kentromieliki adinamia arxika (den mporei na sikwthei apo vathi kathisma-Simeio Gower) ,se epidinwsi exoume liknistiko vadisma,lordwsi osfiis,psevdoipertrofia gastroknimiwn(enapwthesi sindetikou kai lipwdous isto),vraxinsi miwn!!,prosvalei kai anapnevstikous kai miakardio kataligoun sta 20

Question 10

ergastiriaka stin Duchenne

Answer 10

Ck avksimeni,diataraxes agwgimotitas stin kardia,miopathitika evrimata sto img,meta apo biopsia se anosoistoximikes texnikes exoume elleipsi distrofinis ,kai miriako genetiko elexo eleipsi diplasiasmo i metalakseis gonidiou tis

Question 11

pathogeneia Duchenne

Answer 11

eleipsi distrofinis>disleitourgeia kitarikis memvranis>anekselekti eisroi iontwn ca>diergasies katavolismou>nekrwsi miikis inas

Question 12

antimetwpisi Duchenne

Answer 12

den iparxei therapeia ,alla epitinoun ton xrono o kidemonas ta kortikoeidi kai psixologiki ipostiriksi

Question 13

miiki distrofia Becker

Answer 13

kaloithis filosindeti miiki distrofia,distrofinopatheia opou iparxei mikri posotita fisiologikis distrofinis ,oi thigateres twn asthenwn einai ipoxrewtikoi foreis

Question 14

miiki distrofia emery dreifuss

Answer 14

filosindeti sto x provlima me tin prwteini emerini,adinamia kai atrofia omovraxioniwn kai peroniaiwn miwn,miikes vraxinseis(eikona agkwnes se kampsi),aitia thanatou kolpokoiliakos apokleismos(miokardiopatheia)

Question 15

prosopo omo vraxionios miiki distrofia

Answer 15

epikratitika metavivazomeni,prosvoli miwn prosopou kai omikis perioxis,,exoume pterigoeidis omoplates(apokolisi tous),provlima stous prosthious knimiaious mies(ptwsi akrou podos),atrofia di kai tri kefalwn,deltoeidis k.f,ekdilwsi 1-2 dekaetia ,kleides orizontiwmenes,adinamia prosopikwn miwn

Question 16

ergastiriaka enzima prosopoomovraxionios miikis distrofias

Answer 16

miika enzima avksimena,img miopathitikou tipou ,gwniwdeis atrofikes miikes ines stoixeio nevrogenous vlavis

Question 17

miotoniko fainomeno

Answer 17

paratasi aposispasis tou mios xaraktirizei miotonikes pathiseis,vioximikos logos :metalakseis gonidiwn pou kodikopoioun diavlous cl na i prwteinikis kinasis pou epireazei ton diavlo

Question 18

miotoniki distrofia (nosos steinert)

Answer 18

i miotonia metadidete epikratitika polisistimatiki nosos ,kanei atrofia kai adinamia miwn(sternokleidomastoeidous ,krotafiti ,prosopikwn,ptwsi vlefarou) epomenos kanei sigkekrimeno prosopoeio me metwpiaia falakra,disfagia enrini omiliaw,atrofia orxewn ,katarakti ,kardiaki kai anapnevstiki aneparkeia,diskoiliotita

Question 19

ergastiriaka evrimata miotonikis distrofias (nosos steinert)

Answer 19

ck arxika filiologiki,img miotonikes ekfortiseis(dinamika pou epanalamvanountai me avksomiomeno ipsos)-miopathitikou tipou evrimata, stin biopsia exoume: atrofia inwn tipou 1 ,daktilioeidis ines ,kentrikoi oi pirines kai athriseis tous

Question 20

poio einai to ipefthino gonidio stin miotoniki distrofia

Answer 20

to xr 19 pou kodikopiei tin miotonini i metalaksi ginete logo avksimenou arithmou CTG

Question 21

sigkenis miotonia

Answer 21

thomsen(epikratitiki) kai i becker,metalasete to xr 7 pou kodikopiei diavlo xlwriou memvranis miikwn inwn,i miotonia ekdilwnete stis ekousies kiniseis-> ipetrofia miwn,img–>miotonikes efkortiseis

Question 22

kakoithis iperthermia apo ti prokaleitai

Answer 22

apo ptitika anaisthitika tipou alothanis,kkai apopolotika mioxalarwtika tipou souksinilxolinis kata tin geniki anaisthisia

Question 23

ti ginete stin kakoithi iperthermia

Answer 23

diatarasete i rithmisi ca ,ca apeleftherwnete apo sarkoplasmatiko diktio—>paratetameni miiki sispasi

Question 24

kliniki eikona kokoithous iperthermias

Answer 24

diskapsia,taxikardia arithmia,iperthermia,iperkapnia oksewsi,ravdomiolisi kai iperkaliaimia……therapeia me dandroleni(mioxalarwtiko anastelei tous diavlous ca sto sasrkoplasmatiko diktio)

Question 25

sindromo MELAS

Answer 25

MITOXONDIRAKI EGKEFALOMIOPATHEIA me galaktiki oksewsi kai egkefalika epeisodia

Question 26

flegmonwdeis miopatheies xxwrizontai se :

Answer 26

flegmwni apo gnwstous loimwdeis paragontes kai idiopathis flegmoni

Question 27

klinikes ontotites idiopathwn flegmonwdwn miopatheiwn

Answer 27

dermatomiositida,polimiositida kai i miositida me egkleista

Question 28

idiopatheis flegmonwdeis miopatheies:dermatomiositida,polimiositida

Answer 28

kentromieliki miiki adinamia pou mporei na ksekinisei me pireto,simetexoun sixna trixilikoi mies,farigka kai oisofagou->disfagia,fenomeno raynaud,kai dermatikes aloiwseis stin dm(fotoevaisthito eksanthima),pithanes diataraxes tis kardias,mporei na sindeete me kakoitheies

Question 29

i polimiositida kai dermatomiositida siniparxoun me nosous tou sindetikou istou paradeigmata..

Answer 29

sel.r/a, sklirodermia,sjogren klinika kanoun …miositides,raynaud,arthritides,orogonitides(sel),sklirodaktilia

Question 30

i polimiositida kai dermatositida(idiopathis) mporei na sindeontai me

Answer 30

kardiakes arithmies ,noso sindetikou istou ,kakoitheis neoplasies

Question 31

ergastiriaka evrimata pm/dm

Answer 31

avksimena epipeda ck(exoume nekrwtiki vlavi),transaminases,aldolasi,galaktiki deidrogenasi ,img->polifasika dinamika mikrou ipsous vraxeias diarkeias kai aftomati drastiriotita( endeikseis miopatheias) se viopsia ->flegmoni(apo cd8 t lemfokitara kata memvranis miikis inas)

Question 32

pathogeneia dermatomiositidas

Answer 32

energopoiitai to simplirwma kai enapothesi simplegmatwn katastrofis memvranis (MAC) sta trixoeidi,cd8 stous mies

Question 33

therapeia dm/pm

Answer 33

therapeia kortikosteroeidi(prednizoni) i anthektika se methotreksati,endoflevia xorigisi g sfairinis

Question 34

sinithesteri flegmonwdeis miopatheia se ilikiomenous

Answer 34

miositida me egkleista,asimmetri prosvoli tetrakefalwn,kamptirwn karpou,kanei disfagia,ck fisiologiki,se biopsia exoume flegmonwdi diithisi kai iwsinofilika kittarosplasmatika egkleista den antapokrinete se therapeies

Question 35

Ο Μυόκλονος

Answer 35

Ο μυόκλονος χαρακτηρίζεται από απότομες, αστραπιαίες, σύντομες ακούσιες κινήσεις. Μπορεί να είναι φυσιολογικός (νυχτερινός, λόξυγγας), ιδιοπαθής (μυοκλονική δυστονία), επιληπτικός, συμπτωματικός (όπως σε προϊούσες εγκεφαλοπάθειες ή σε άνοιες) ή μεταβολικός (νεφρική ή ηπατική ανεπάρκεια, υποξία κτλ). Από πλευράς φαινομενολογίας διακρίνεται ανάλογα με το εύρος του, την κατανομή του (εστιακός, τμηματικός …), τη συμμετρία του (συμμετρικός ή ασύμμετρος) και τις συνθήκες εμφάνισής του (αυτόματος ή προκλητός από ερεθίσματα πχ κίνηση, θόρυβο, φως).

Question 36

miotoniko fainomeno

Answer 36

paratasi tis aposispasis tou mios,xaraktirizei tis miotonikes pathiseis