JM Chapter 22 Flashcards
combined LMN muscle atrophy plus
UMN hyper-reflexia, leading to progressive spasticity. This is the most common typ
amyotrophic lateral sclerosis (Lou Gehrig disease)
- wasting beginning in the distal muscles; widespread
fasciculation
progressive muscle atrophy
Results in wasted I tongue, weakness of chewing and swallowing, and
of facial muscles
progressive bulbar (LMN) palsy and pseudobulbar palsy (LMN lesions in the brain stem
motor nuclei
The hand tremor is most marked with the arms supported c
the lap and during walking.
The characteristic movement is ‘pill-rolling’
The resti
tremor decreases on finger-nose testing. The best way to evoke the tremor is to distract the
patient, such as focusing attention on the left hand with a view to ‘examining’ the right hand o
by asking the patient to turn the head from side to side.
Resting tremor-Parkinsonian
This fine tremor is noted by examining the patient with the arms outstretched and the fingers
apart.
The tremor may be rendered more obvious if a sheet of paper is placed over the dorsum
the hands.
The tremor is present throughout movement, being accentuated by voluntary
Action or postural tremor
This coarse oscillating tremor is absent at rest but exacerbated by action and increases as the
target is approached.
IT occurs in cerebellar lobe disease, with
lesions of cerebellar connections and with some medications.
Intention tremor (cerebellar disease)
A flapping or ‘wing-beating’ tremor is observed when the arms are extended with
hyperextension of the wrists. It involves slow, coarse and jerky movements of flexion and
extension at the wrists.
Flapping (metabolic tremor)
Triad of features
Positive family history
Tremor with little disability
Normal gait
Essential tremor
Pakinsonsm
Positive frontal lobe signs,
Pakinsonsm
grasp and glabellar taps
is the gold standard for therapy
Pakinsonsm
L-dopa
Anxiety / depression
Impaired vision
Diplopia
Ataxia
vertigo
Numbness / paresthesia /
Band sensation around trunk or limbs
Bladder urgencies
Incontinence
Constipation
Mor3 common in females
Facial palsy
Trigeminal neuralgia
MULTIPLE Sclerosis
Inv of Multiple sclerosis
Lumbar puncture
MRI
In outpatient setting the tx for Multiple Sclerosis for moderate relapse
PREDNISOLONE
For mild relapse, tx for multiple sclerosis is
Rest and assurance
Severe relapse of attacks of MS tx is
Methylprednisolone 1f in 200 ml, saline by slow IV infusion daily for 3 days
What isbthe tx of spasticity in MS
Physiotheraoy
baclofen 10-25mg note
Alternative: Dantroleme
Tx for Paroxysmal eg neuralgia
Carbamazepine or Gabapentine
Classic glove and stocking sign
Peripheral Neuropathy
Reflexes absent
Both proximal and distal muscles affected
Csf protein elevated
GBS
Tx of GBS
Physiotherapy
Tracheostomy and artificial ventilation
Plasma exchange or IV Ig (0.4 G/KG DAY FOR 5 DYS)