JM Chapter 14 Flashcards
TSH receptor antibodies (TR Ab):
Graves disease
Thyroid peroxidase antibodies (TPO Ab):
Hashimoto disease
Thyroglobulin antibody (Tg Ab):
Hashimoto disease
The term refers to the accumulation of mucopolysaccharide in subcutaneous
tissues.
Tiredness +HUSKY VOICE + cold intolerance
Myxoedema
Common causes of primary hypothyroidism include
radioactive iodine treatment, thyroid surgery
and Hashimoto 1thyroiditis
Patients at risk for primary hypothyroidism
Previous Graves disease
Autoimmune disorders (e.g.autoimmune lymphocytic thyroiditis, rheumatoid arthritis, type 1
diabetes)
Down syndrome
Turner syndrome
Drug treatment: lithium, amiodarone, interferon, iodine
Previous thyroid or neck surgery
Previous radioactive iodine treatment of the thyroid
Clinical Features of Primary hypothyroidism
Constipation
Cold intolerance
tiredness/lethargy/somnolence
physical slowing
mental slowing
depression
huskiness of voice
puffiness of face and eyes
pallor
loss of hair
weight gain
is an autoimmune thyroiditis, is the
commonest cause of bilateral non-thyrotoxic goitre in Australia.
firm and rubbery
patients may be hypothyroid or euthyroid
Hashimoto thyroiditis, or lymphocytic thyroiditis
Confirmatory Teats:
(TPO Ab) titre
and/or fine-needle aspiration cytology.
Most common cause
of hyperthyroidsim
(Thyrotoxicosis)
Graves disease
Followed by nodular thyroid disease
What are the other causes of Hyperthryoidism ?
Graves disease (typical symptoms with a diffuse goitre and eye signs)
Autonomous functioning nodules/toxic adenoma
Subacute thyroiditis (de Quervain thyroiditis) viral origin (suspect if painful thyroid and
malaise)
Excessive intake of thyroid hormones thyrotoxicosis factitia
Exogenous iodine excess, e.g. food contamination
Amiodarone (beware of this drug)
What are the Clinical features of Hyperthyroidsm?
Heat intolerance
Sweating of hands
Muscle weakness
Weight loss despite normal or increased appetite
Emotional lability, especially anxiety, irritability
Palpitations
Frequent loose bowel motions
Physical examinations
Hyperthyroidism
Signs are (usually):
agitated, restless patient
warm and sweaty hands
fine tremor (place paper on hands)
goitre
proximal myopathy
hyperactive reflexes
bounding peripheral pulse
+ atrial fibrillation
DxT anxiety + weight loss + weakness
Thyrotoxicosis
Eye signs of
Hyperthyroidism
Lid retraction (small area of sclera seen above iris)
Lid lag
Exophthalmos
Ophthalmoplegia in severe cases
Investigations
Hyperthyroidism
T4 (and T3) elevated
TSH level suppressed
Radioisotope scan
Antithyroid peroxidase (TPO Ab) often positive
Treatment for Hypothyroidism
Levothyroxine (thyroxine) 50-100 mcg daily up to 200 mcg daily
Aim TSH levels of 0.5-2mUL
Treatment of Hyperthyroidism
Radioactive iodine therapy
Thionamide antithyroid drugs (initial doses)
*carbimazole 10-45 mg (o) daily starting with 10-20 mg in divided doses depending on
disease activity
or
*propylthiouracil 200-600 mg (0) daily in divided doses or methimazole
Adjunctive drugs:
beta blockers propranolol 10-40 mg, 6 to 8
hourly); diltiazem or atenolol are alternatives
Lithium carbonate (rarely used when there is intolerance to thionamides)
Lugol’s iodine: mainly used prior to surgery
Surgery
Page 140
What are the surgical treatment for Hyperthyroidism
Subtotal thyroidectomy or Total Thyroidectony
Thyroid enlargement may be diffuse or multinodular. Diffuse causes include physiological,
Graves disease, thyroiditis (Hashimoto or de Quervain), iodine deficiency or it can be hereditary
Goitre
Investigations include
Goitre
TFTs, needle biopsy, ultrasound and CXR.
Management
Goitre
Supportive thyroxine if TSH elevated (may lead to marked regression) and subtotal or total thyroidectomy
It is defined as a discrete lesion on palpation and/or ultrasonography that is distinct from the rest of the thyroid gland.
Thyroid nodules
Causes of Thyroid Nodules
Dominant nodule in a multinodular goitre (most likely)
Colloid cyst
True solitary nodule: adenoma, carcinoma (papillary or follicular)
Investigations
Investigations of Thyroid Nodule
Ultrasound imaging
Fine-needle aspiration cytology
Thyroid function tests
The main presentations of Thyroid carcinoma are
painless nodule,
a hard nodule in an enlarged gland or
lymphadenopathy.
Most common thyroid malignancy
Papillary carcinoma
is the investigation of choice of Thyroid Carcinoma
Fine-needle aspiration
Hyperprolactinaemia”
main causes (of many) are a pituitary adenoma (prolactinoma; micro- or macro),
pituitary stalk damage, drugs - such as
antipsychotics, various antidepressants, metoclopramide,
cimetidine, oestrogens, opiates, marijuana - and physiological causes such as pregnancy and
breastfeeding.
Clinical features
Hyperprolactinaemia
Symptoms common to males and females: reduced libido, subfertility, galactorrhoea (mainly
females)
Females: amenorrhoea/oligomenorrhoea
Males: erectile dysfunction, reduced facial
Hyperprolactinaemia
Diagnosis
Serum prolactin and macroprolactin assays
MRI:if there is headache
DxT nasal problems + fitting problems (e.g. rings, shoes) + sweating -
acromegaly
Acromegaly
Symptoms of Acromegaly
Symptoms suggestive of acromegaly include:
excessive growth of hands (increased glove size)
excessive growthof tissues (e.g. nose, lips, face)
excessive growth of feet (increased shoe size)
increased size of jaw and tongue; kyphosis
general: weakness, sweating, headaches
sexual changes, including amenorrhoea and loss of libido
disruptive snoring (sleep apnoea)
deepening voice
What is the key test fpr investigating Acromegaly?
IGF-1
Diagnosis of
Acromegaly:
:
Plasma growth hormone excess
Elevated insulin-like growth factor 1 (IGF-1) (somatomedin) the key test
X-ray skull and hands
MRI scanning pituitary
Consider associated impaired glucose tolerance/diabetes
Treatment options of
Acromegaly
Transsphenoidal pituitary microsurgery, drugs and radiotherapy