Jia. 2018. A New Approach To Cerebral Palsy: Discussion Of The Effective Components Of Umbilical Cord Blood And Its Mechanisms Of Action

Question 1

What hope is there of umbilical cord blood for CP (2 big reasons)?

(Jia. 2018)

Answer 1

1. Scientifically plausible tratement

2. Possible cure for CP

Question 2

What can be impact of CP cause in the brain?

Jia, 2018

Answer 2

Hypoplastic brain tissue, resulting in loss of Neuron function

Question 3

What are the different causes of CP? (What 4 things listed)

Jia, 2018

Answer 3

Caused by multiple of things including

1. hypoxia inducted brain damage
2. genetic factors
3. mutations
4. And other hypothesis- including therapies of infection/inflammation)

Question 4

What other things do paitients have with CP? (7 things and their % prevalence)

(Jia, 2018)

Answer 4

1. Pain- 75%
2. Intellectual disability 50%
3. Inability to walk 33%
4. Inability to talk 25%
5. Epilepsy 25%
6. Incontinence 25%
7. Blindness 10%

Question 5

There are 6 reasons why umbilical cord blood has advantages over other types of stem cell

(Jia 2018)

Answer 5

1. Treatment safety and efficacy
2. Ethics
3. Non-neoplasticism proliferation
4. Accessibility
5. Ease of preservation
6. Regulation of immune response (based on findings from animal and clinical trials)

Question 6

What are the three aspects of UCB interventions for CP?

Jia 2018

Answer 6

1. Homing and neurogeneration
2. Trophies factor degradation
3. Neuroprotective effects

Question 7

In CP animal studies stem cells have shown good results depending on what two factors?

(Jia 2018)

Answer 7

1. Self renewal: the capacity to generate identifiable cells

2. Multipotency: capacity to generate many cell types

Question 8

In animal studies using UCB substantial progress has been shown in three areas:

Answer 8

1. Migration to sites
2. Improvement of functional loss
3. Prevention of white matter damage