2018. McDonald Et Al. Umbilical Cord Blood Cells For Treatment Of CP

Question 1

Do scientists fully understand the mechanisms of UCB?

McDonald et al. 2018

Answer 1

Not fully understood

Question 2

What makes UBC very safe to consider for CP?

McDonald et al. 2018

Answer 2

Been used for almost 30 years for other conditions

Question 3

What did studies in rodents with strokes first reveal about UCB to reduce brain injury? (3 things)

(McDonald et al. 2018)

Answer 3

1. Cells shown to migrate to sites of injury within the brain
2. When given intravenously reduced functional deficits
3. Protected against white matter injury

Question 4

Other than the specific stem and progeenitor cell populations within UBC, what other property types do UBC have to support brain injury repair?

(McDonald et al. 2018)

Answer 4

A. Anti-inflammatory

2. Anti-apoptotic (reduce cancer)
3. Antioxidant potential (fight free radicals ect)
4. May mediate repair of cerebral artictecturhe (vascular remodelling ore re-establishment of neuronal networks)

Question 5

What areas need more work for UCB for CP? (5 areas listed)

McDonald et al. 2018

Answer 5

1. consensus on an optimal dose
2. cell type
3. mode of delivery
4. timing of administration
5. the potential for targeted therapy in both infants and children who are diagnosed with brain injury.