2016. Novak Et Al. Concise Review: Stem Cell Interevention For People With CP

Question 1

What overall impact do stem cells seem to induce for patents with CP?

(Novak et al. 2016)

Answer 1

Short term improvements in motor skills

Question 2

Why did stem cell scientists and CP experts unanimously advise that cell replacement therapists might be particularly effective?

(Novak et al 2018)

Answer 2

1. Because the brain damage is often regionally restricted, non progressive and appears limited to few cell types
2. CP involved demyelination Whw-Wge process common to other diagnosis already pioneering stem cell research

Question 3

List three mechanisms by which stem cells might treat CP?

Novak et al 2016

Answer 3

1. Regenerative mechanisms: Replacement and/or rep are of damaged brain cells, which may or may not include differentiation
2. Anti-inflammatory mechanisms
   - A reduction int he release of excitetoxins, cytotoxic, and oxygen free radicals
   - If used early enough might evoke a protective response- that reduces the size and extent of the white matter injruy
3. Trophies mechanisms
   - To promote cell survival
   - Induce endogenous cell migration, proliferation and differentiation

Question 4

What has hampered scope for patient-based clinical trials for CP?

(Novak et al 2016)

Answer 4

Lack of valid animal model for such a heterogenous condition

Question 5

What is umbilical cord blood (UCB)?

Novak et al 2016

Answer 5

Complex internal environment rich in variety of stem and progenitor cell populations