2013 Boyd article: Promoting neuroplasticity for motor rehabilitation after stroke considering the effects of aerobic exercise and genetic variation on BDNF Flashcards

1
Q

What are two postroke rehabilaition strategies that consider the importance of BDNF from the Boyd 2013 paper:

A

The use of aerobic exercise to enhance brain function

and the incorporation fo genetic information to individualised therapy

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2
Q

Rehabilitation strategies that optimise BDNF effects on neuroplasticity may be especially effective at what?

(Boyd, 2013)

A

Improving motor function post stroke

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3
Q

When utilising BDNF rehabiliation strategies common genetic variants can reduces what?

(Boyd, 2013)

A

The secretion of the BDNF protein, so individualised motor rehabilaition strategies are needed

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4
Q

Neuroplasticity defined as:

(Hint CNS)

(Boyd, 2013)

A

Ability of the CNS to undergo structural and functional change in response to new experiences

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5
Q

Despite major progress in understanding neuroplasity..

Boyd, 2013

A

Very few new treatment interventions have resulted from this research

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6
Q

BDNF is a member of what family? And has been identified as a key to mediate what?

A

Is a member of the neurotrophin family, a group of proteins involved in neuroprotection, neurogenesis and neuroplasticity

and has been identified as a key mediator of motor learning and rehabilation after stroke

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7
Q

Aerobic exercise affects the brain indirectly and directly how?

(Hint- what pathways direct?)

(Boyd, 2013)

A

Indirectly through improvements in general health and fitness

Directly through alternations in molecular signally pathways that act directly on the CNS

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8
Q

Is Aerobic exercise the only exercise to have this impact on neuroplasticity?

(Boyd, 2013)

A

No, resistance exercise has a growing body of evidence

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9
Q

Evidence shows that exercise induced increases in BDNF benefit what function?

(Boyd, 2013)

A

Cognitive function

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10
Q

How long are systematic levels of BDNF increased following a bout of aerobic exercise in humans?

(Boyd, 2013)

A

Answer: 10-60 minutes

And also shown in one study when used before, or after (Roig)

Question: Is there any more recent evidence on this?

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11
Q

A large meta-analysis of 18 aerobic exercise training interventions studies in older adults concluded that the largest effects on cognition occur on what?

(Body 2013)

A

Executive control domain, including functions such as planning, scheduling, working memory, and multi-tasking

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12
Q

Is there any evidence that the benefits of aerobic exercise on brain function persists at follow up if exercise stopped?

(Boyd, 2013)

A

Not that the authors are aware of

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13
Q

Does aerobic exercise itself induce neuroplasticity?

Boyd 2013

A

No, rather it promotes the development of a neural environment that is supportive of plasticity

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14
Q

Pairing aerobic exercise in close temporal proximality with behavioural training will serve to prime what area for neuroplastic chance?

(Boyd, 2013)

A

The CNS

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15
Q

The intensive of exercise should be great than what?

Boyd 2013

A

30% of heart rate reserve but based on individual exercise stress test results and health status

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