JAALAS 2012 No. 2

Question 1

1. Milk production in rats peaks:
   a. At the beginning of lactation
   b. Towards mid lactation
   c. Towards the end of lactation

Answer 1

B

Question 2

2. Albumin in the mother’s milk originates from plasma in rats. T or F

Answer 2

True

Question 3

True or False. Saguinus oedipus are listed on the critically endangered species list.

Answer 3

True

Question 4

Cotton-top tamarins are animal models of:

Answer 4

2. Spontaneous ulcerative colitis, colonic adenocarcinoma, Epstein-Barr Virus, early Alzheimer disease

Question 5

Serum glucose levels in Saguinus oedipus were (higher/lower) when compared to other adult Old and New World nonhuman primates.

Answer 5

Higher

Question 6

T/F: Hypoxic and hypercapnic conditions develop more quickly in disposable than nondisposable individually ventilated cages.

Answer 6

False

Question 7

T/F: NH3 levels did not reach detectable levels at any time point in this study.

Answer 7

True

Question 8

List some disadvantages of autoclaving bedding material.

Answer 8

Disadvantages of autoclaving bedding material include: personnel time, autoclave energy consumption and maintenance costs, and potential loss of absorptive capacity of the bedding material.

Question 9

Which governing body has set the human exposure limit for ammonia?

a. Occupational Safety and Health Administration
b. The United States Department of Labor
c. The American Conference of Governmental Industrial Hygienists

Answer 9

C

Question 10

What is the human exposure limit used as a guideline in this study?

Answer 10

25ppm ammonia for an 8-h limit

Question 11

1. What is an example of a common stereotypy in Meriones unguiculatus?
   a. Digging
   b. Back flips
   c. Self –injurious behavior
   d. Circling to the right

Answer 11

A

Question 12

1. T/F. In addition to their low implementation costs, microfans are readily commercially available, require little to no maintenance, and have an expected mean lifespan of 20,000 hours under constant operation.

Answer 12

True

Question 13

Define ASHRAE

Answer 13

2. American Society of Heating, Refrigerating and Air-Conditioning Engineers

Question 14

True/False: Both in human operating rooms and rodent vivaria, use of shoe covers provides useful protection for the patient or animal.

Answer 14

False

Question 15

“Contamination” powder was found on which of the following in the rodent room when simulated husbandry tasks were complete?

a. Mouse cage
b. Biosafety cabinet
c. Floor
d. Step stool
e. Bottom rung of cage rack

Answer 15

C, D, E

Question 16

1. What disease can be caused by Corynebacterium bovis in mice, and what strain of mice is it observed in?

Answer 16

Hyperkeratosis or scaly skin disease which occurs in athymic nude mice.

Question 17

Which type of screening method is this paper advocating?

a. High-sensitivity, low specificity followed by low-sensitivity, high-specificity for those that come up positive in the initial screen?
b. Low-sensitivity, high specificity followed by high-sensitivity, low-specificity for those that come up positive in the initial screen?

Answer 17

A

Question 18

What is one reason that C57/BL6 mice and Swiss Webster mice have different IgE responses to mite infestations?

Answer 18

C57/BL6 mice have primarily a Th1-type cytokine response, therefore the rise in IgE is less than in Swiss Webster mice

Question 19

How long is the life cycle of each of the following mites: Myobia, Myocoptes, Radfordia?

Answer 19

Myobia 23 days, Myocoptes 8 days, Radfordia thought to be close to Myobia

Question 20

T/F. All 3 protocols provided reliable anesthesia in mice with a short recovery phase.

Answer 20

True

Question 21

T/F. Both premedication groups regimens shortened the time required to reach immobilization after exposure to S when compared to S alone.

Answer 21

True

Question 22

During the first 12 hours after anesthesia which of the following was true?

a. Heart rate increased significantly over baseline in 2 of 3 groups.
b. Body weight decreased moderately from baseline values.
c. Core body temperature was significantly lower than baseline values.
d. Locomotion was unchanged from baseline values in all 3 groups.

Answer 22

D

Question 23

T/F. Two mice died during the study, one KS and one FMS.

Answer 23

F. Both were KS mice

Question 24

Which of the following reflexes was not tested as noxious stimuli in this study?

a. Pedal withdrawal reflex
b. Palpebral reflex
c. Skin pinch reflex
d. Tail pinch

Answer 24

B

Question 25

1. Benzimidazoles are an extensively studied drug often requiring the use of laboratory rodents for toxicology studies. Which of the following has NOT been linked with this drug?
   a. Antiparasitic compound
   b. Antifungal compound
   c. Alzheimer treatment
   d. None of the above

Answer 25

D

Question 26

2. Which of the following is an advantage of using honey as a carrying compound?
   a. Cheap and easily available
   b. Antimicrobial properties
   c. Viscosity allows easily emulsification of drugs
   d. All of the above

Answer 26

D

Question 27

1. Infections with pinworms in rodent colonies can
   a. Be asymptomatic
   b. Cause rectal prolapse and intussusceptions
   c. Hematologic changes
   d. Hair loss
   e. a, b, c
   f. All of the above

Answer 27

E

Question 28

2. T or F: In rodents, more than 90% of fenbendazole is excreted in the feces unchanged

Answer 28

True

Question 29

3. T or F: In rodents colonies, only the animals that test positive for pinworms should be treated

Answer 29

3. False; diagnostic tests for pinworms often yield false-negative results in low-level infections, and treating only those mice proven to be infected can leave undetected pockets of infected animals that can serve as a source of recurrent infections within the facility

Question 30

1. What substance was used to induce pulmonary hypertension in the rats used in this study?

Answer 30

1. Monocrotaline

Question 31

2. The telemetry device tested allows for the simultaneous collection of pulmonary and systemic blood pressures in conscious animals. (T or F)

Answer 31

True

Question 32

1. T/F. The submandibular approach is a reliable method of collecting blood samples in the cotton rat.

Answer 32

False

Question 33

2. Use of which gauge needle is recommended for the subzygomatic method.

Answer 33

18 G

Question 34

3. T/F. Landmarks for the subzygomatic arch include the intersection of the zygomatic bone and the maxilla.

Answer 34

3. F. Landmarks are the zygomatic bone and the mandibular ramus.

Question 35

4. Which other blood collection site may also be suitable in the cotton rat?

Answer 35

The sublingual vein.

Question 36

18F-flurodeoxyglucose is a glucose analog so it useful for evaluating glucose metabolism in various tissues. T/F

Answer 36

T - this radiotracer is used for evaluating glucose metabolism in heart and brain.

Question 37

The anesthetic regimen is not relevant when comparing results from PET scans with radiotracers. T/F

Answer 37

F - the anesthetic regimen needs to be standardized in order to compare results when evaluating PET with radiotracers since anesthetics have an effect on how the radiotracer is metabolized and blood flow and pressure to the various organs differs with different anesthetic regimens.

Question 38

T/F. The African Clawed Frog may not be housed in an area where a device emitting a sound pressure level of more than 95 dB is in use?

Answer 38

F. There are currently no published threshold recommendations for vibrations and noise exposure levels for Xenopus.

Question 39

T/F. The lateral lines of the African Clawed frog can be used for sexual dimorphism.

Answer 39

False