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JAALAS > JAALAS 2011 No. 2 > Flashcards

JAALAS 2011 No. 2 Flashcards

1
Q

Type 2 Diabetes Mellitus is most commonly associated with advancing age and obesity. True or False?

A

True

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2
Q

FBG levels of greater than 80 mg/dL and HbA1c concentrations exceeding 4.7% appear to be diagnostic of early or pre Type 2 Diabetes Mellitus in Rhesus Monkey. True or False?

A

True

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3
Q

HbA1c values do not show species specific variations. True or False?

A

False

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4
Q

In chimpanzees, FBG levels of greater than 100 mg/dL and HbA1c concentrations exceeding 5.0% appear to be diagnostic of over diabetes. True or False?

A

True

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5
Q
  1. T/F: Environmental enrichment generally includes anything that is preferred by captive animals.
A

True

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6
Q
  1. Excessive hair-pulling is an abnormal behavior that has been reported in the following species:
    a. Humans
    b. Primates
    c. Mice
    d. Dogs
    e. All of the above
A

E

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7
Q
  1. T/F: Barbering behavior decreases with age.
A

False

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8
Q

True or False: Group housing didn’t decrease the heart rates in undisturbed male and female rats, of either strain, when housed in the same room with singly housed rats.

A

True

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9
Q

In this study, which of the following rat strains had elevated heart-rate responses to acute procedures?
A. Wistar
B. Holtzman Sprague-Dawley
C. Spontaneously Hypertensive Rat (SHR)

A

B

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10
Q
  1. Which analgesic took the longest time for mice to return to presurgical locomotor activity?
A

Flunixin meglumine

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11
Q
  1. Which analgesic took the longest time for mice to return to presurgical body weight?
A

Flunixin meglumine

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12
Q
  1. Current data suggest that which 2 analgesics are suitable analgesics after major abdominal surgery in mice?
A

Meloxicam and buprenorphine

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13
Q
  1. In a recent article which analgesic did not have any effects on pain attenuation in a surgical model of pain in rats?
    a. Tramadol
    b. Buprenorphine
    c. Tramadol+Gabapentin
A

A

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14
Q
  1. T/F. Gabapentin acts on GABA receptors to ameliorate neuropathic pain?
A

False

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15
Q

Undesirable side effects or characteristics of buprenorphine use in rats can include:

a. Loss of body weight
b. Pica
c. Lack of efficacy vs. other opioids
d. All of the above

A

D

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16
Q

T/F. One dose of buprenorphine sustained-release injection at 1.2 mg/kg provided analgesia to rats for 2-3 days.

A

True

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17
Q

What of the following is not a mode of action of buprenophine as an analgesic?

a. Partial agonist at the μ-opioid
b. κ-opioid receptor antagonist
c. δ-receptor agonist
d. Full agonist at the μ-opioid

A

D

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18
Q

T/F. A non-specific increase in general activity level after buprenorphine administration has been observed in both mice and rats.

A

True

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19
Q
  1. What are the benefits of premedication with an opioid-sedative combination?
A
  1. Reduction in stress, easier animal handling, preemptive analgesia, reduction in inhalant anesthetic requirements and less cardiovascular and respiratory depression.
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20
Q
  1. The authors named this drug as a highly effective reversal agent for sedation caused by Midazolam and Buprenorphine combinations. Name the agent.
A

Flumazenil

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21
Q
  1. How should arterial blood gases be stored before analysis? Why?
A
  1. They should be stored on ice. If not held on ice, pO2 values will decrease.
22
Q
  1. Pruritis was exhibited by titi monkeys after administration of oxymorphone, but not rhesus. T/F
A

False

23
Q
  1. Which species exhibited a longer half life of oxymorphone?
    A. Titi monkeys
    B. Rhesus monkeys
A

A

24
Q 
3.	Respiratory rates were lower in which species of monkey after oxymorphone?  
A.	Rhesus  
B.	Titi  
C.	Neither 
D.	Both
A

D

25
Q
  1. The study established that New World monkeys are more sensitive to opioids than Old World monkeys? Y/N
A

No

26
Q

What is the cause of UD?

A

Multifactorial, but may include diets high in vitamin A or fat, stress, mites, deficiency in nitric oxide synthase.

27
Q

What is the mechanism of action of maropitant citrate?

A

NK1 receptor antagonist

28
Q

T or F? Treating for 10 days is more effective that 5 days.

A

F - They were equally effective

29
Q

What class of drug is ketoprofen?

A

NSAID

30
Q

What class of drug is buprenorphine?

A

Opioid

31
Q

In a recent article, which approach to surgical placement of a radiotelemetry device was most beneficial to mice?

a. Midline incision
b. Subcutaneous
c. Flank incision
d. All approaches had the similar results

A

C

32
Q
  1. Macaca radiata originates from what country?
A

India

33
Q
  1. Cardiac Time Intervals need to be adjusted for what parameter, depending on the species being measured?
A

Heart rate

34
Q
  1. Cardiac Time Intervals are a means of assessing what function?
A

Left Ventricular Function

35
Q

Intravenous inoculation of M tuberculosis requires a lower infective dose that aerosol exposure to create pulmonary and extrapulmonary lesions in mice (T/F)

A

False

36
Q

The drug commonly used to treat M tuberculosis in humans, and the one that when used in this case report did not result in granulomas of the middle ear is:

a. Moxifloxacin
b. Rifampin
c. Isoniazid
d. Pyrazinamide

A

C

37
Q

In addition to the middle ear the most common sites for exptrapulmonary lesions in mice intravenously inoculated with M. tuberculosis are:

a. Spleen and Kidney
b. Spleen and CNS
c. CNS and Kidney
d. Liver and Kidney

A

B

38
Q 
Rabies virus belongs to which of the following viral genera?
A.  	Lyssavirus
B.  	Nanovirus
C.  	Orthoreovirus
D.  	Idnoreovirus
E.  	Bornavirus
A

A

39
Q

Which of the following methods were used to characterize rabies infection status in this study?
A. Direct fluorescent antibody testing of the brainstem
B. Virus detection in oral swab samples
C. Virus-neutralizing antibody detection in serum and cerebrospinal fluid
D. Histopathology of nervous system tissues
E. All of the above were used to characterize rabies infection in this study

A

E

40
Q

Which of the following factors is NOT implicated in an enhanced chance of survival after rabies infection?
A. Route of virus inoculation; intraperitoneal and mucosal routes are more favorable to survival than intracerebral or intramuscular exposure
B. More dilute viral concentrations in the inoculum
C. Age of the host at time of infection
D. Pregnancy status at time of infection
E. Prior exposure to rabies virus

A

D

41
Q
  1. The incidence of neoplasia in nonhuman primates is approximately:
    a. 10%
    b. 2%
    c. 5%
    d. 15%
A

C

42
Q

The P63 marker is specific for:

a. Vascular smooth muscle cells
b. Myoepithelial cells and stromal fibroblasts
c. Myopeithelial cells

A

C

43
Q

T/F. Mammary tissue in non-human primates is focal in distribution.

A

F - It is extensive and diffuse

44
Q

T/F. If sections of tissue are seen with a breached border of positive staining p63 myoepithelial cells then the tumor is likely to be malignant in nature.

A

True

45
Q

T/F. P63 may be a useful prognostic indicator in mammary carcinoma cases in nhps.

A

True

46
Q
  1. What other diagnostic modalities for screening and diagnosing tuberculosis are available?
A
  1. PrimaGam testing (an in vitro assay for interferon gamma response to tuberculin antigens – sensitivity is lower than intradermal tuberculin skin test), thoracic radiographs, gastric lavage with culture, and bronchial alveolar lavage with culture.
47
Q
  1. What organ is affected in Pott’s disease?
A

Spine

48
Q
  1. What test is used to detect anergy?
A

Cell-mediated immunity testing using intradermal injections of antigens such as tetanus toxoid, diphtheria toxoid, and Streptococcus spp. A negative result would indicate a defect in the host’s cell mediated immunity.

49
Q

DJD is a common disease of captive chimpanzees? True/False

A

False

50
Q

Successful treatment of DJD should include:

a. Pain management
b. No treatment is necessary
c. Slow or halt progression
d. a and c

A

D

JAALAS (17 decks)

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