iontophoresis Flashcards

1
Q

iontophoresis

A

current flow between electrodes push ions through skin

i.e drug

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2
Q

T/F iontophoresis is direct

A

true

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3
Q

postive ions flow to the __

A

cathode (neg)

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4
Q

negative ions flow to the __

A

anode (pos)

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5
Q

T/f current flows in both direction in tissue

A

true

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6
Q

can drugs have voltage

A

yes a pos drug can drift towards neg electrode etc..

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7
Q

three was passages across skin happen

A

electomigration
electroporation
electroosmosis

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8
Q

electromigration

A

sweat ducts

hair follicles

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9
Q

electroporation

A

mechanism unknown but skin porosity is increased by estim

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10
Q

electroosmosis

A

bulk movement creates a stream

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11
Q

iontophoresis applications

A

4% acid
2 ma DC
20 mins
5 times in 2 wks

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12
Q

outcome measures iontophoresis

A

pain scale
LEFS
ADLs

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13
Q

iontophoretic equation

A

dosage = current x mins

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14
Q

amount of drug delivered is proportional to:

A

current density, and time of application

how much push and how long the push is

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15
Q

T/f ions is proportional to cube root of current density x time of application

A

tr

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16
Q

dose is proportional to__

A

current magnitude and duration of application

17
Q

clinical doses for iontrophresis range up to _

A

80ma.min

18
Q

for iontophoresis is dosage need lower or upper end of scale

A

upper (70-80)

19
Q

T/f ideal current dosage of iontophoresis is confirmed

A

false yet to be determined - adjust to patient n tolerance

20
Q

current density measure for iontophoresis

A

mA/cm2

21
Q

is electrode size + to conductive surface area

A

no

22
Q

safe current density

A

usually max 1.0 mA/cm at anode

0.5 mA/cm at cathode

23
Q

should you keep cathode or anode surface area larger

A

cathode to keep current tensity lower than anode and reduce risk of skin burn

24
Q

can drugs reach deep tissues from iontophoresis

A

yes and in blood n skin

25
Q

T/F 1-2% of drug concentration is not as good as higher concentrations

A

false

26
Q

which drugs are effect with iontophoresis

A

anti inflammatories

idiopathic hyperhidrosis

27
Q

how much of human tissue is Na Cl

A

70%

28
Q

electrolysis under the electrodes causes _

A

formation of new compounds

29
Q

Under the Anode is

A

acidic reaction

hardening of skin

30
Q

under the cathode is

A

alKaline reaction
stronger

skin softens and burns easily, red itchy

31
Q

why stabilize Ph during treatment

A

buffer

32
Q

T/f at 20-40 mA.min no changes in skin Ph with buffer

A

true but delivering this low of a dose would take too long

33
Q

use buffer?

A

yes if available

34
Q

indications or iontophoresis

A
hyperhidrosis
mm inflammatory disease 
plantar fascitis
TMJ disorder
neuralgia
edema
35
Q

contraindications for iontophoresis

A
damaged skin
sensitivity / allergy to drug
mod/severe sensory impairment 
flammable sprays around
near electronic implants
36
Q

what to tell patient iontophroesis

A

expect redness

37
Q

what to chart iontophoresis

A
drug/ concentration 
ion polarity 
electrode surface area
distance
dosage (ma x min)