inflammation Flashcards
5 cardinal signs of inflammation
Heat
Redness
Swelling
Pain
Loss of Function
goal of minimizing inflammation
minimize collateral damage
stop inflammatory process, down regulate inflammatory signal and get back to normal
why get rid of heat
increases cellular activity
why get rid of redness
its been theres vasodilation (increase in blood flow)
hyperaemia
why get rid of pain
its from pressure of swelling (mechanical) and chemical irrational of nerve
why get rid of swelling
swelling means increased osmotic pressure
and hydrostatic pressure in vessel
osmotic pressure is pulling or pushing
pulling
osmotic pressure
pulling
pressure to prevent flow of water across membrane via osmosis
hydrostatic
pushing
pressure on the walls
by systolic force
what mediates vasodilation
histamine
serotonin
what mediates increased vascular permeability
bradykinin
histamine
serotonin
what mediates chemotaxis
histamine
a bunch of kines
mono, kalli, lympho kines
what mediates fever response
prostaglandiins
what mediates pain
bradykinin
prostaglandins
hageman factor
if theres a vascular response, what changes in the area
vasodilation then constriction
slowing blood flood
accumulation of interstitial fluid
if theres a hemostatic response, what changes in the area
retraction / sealing off blood vessels
formation of platelet clots