Ionophore Toxicosis Flashcards
What are the clinical signs associated with Monensin toxicity in the horse?
- Anorexia
- Sweating
- Abdominal pain
- Stiffness
- Death (within 24-72 hours)
What type of pathological lesion would you see with Monensin toxicity in the horse?
Myocardial necrosis
What type of cardiac changes would you see in a horse with Monensin toxicity?
- AV block
- Atrial fibrillation
- Premature ventricular contractions
- Tachycardia
- Arrhythmia
What type of clinical pathology would you see in a horse with Monensin toxicity?
- Leukocytosis
- Cardiac troponins
- Increased CPK
- Increased AST
- Decreased K, Na, Ca
- Decreased USG
- Increased urine glucose, protein, myoglobin, hemoglobin
To be lethal, cattle would need to receive ____ times their normal dose of Monensin.
10 x
With monensin toxicity, where in the heart would you look for the lesion?
Left papillary muscle
Explain the progression of monensin toxicity in cattle.
Anorexia within 6-12 hours –> diarrhea, weakness, dyspnea in 12-24 hours –> death within 4 days - 6 weeks
What kind of pathological lesions would you see in a cow with monensin toxicity?
- Myocardial necrosis
- Pulmonary edema
- Congestive heart failure
- Liver lesions
When is your PEAK DEATH LOSS in cattle with monensin toxicity?
Within 5-10 days
What kind of lesions does monensin toxicity cause in sheep?
Skeletal muscle necrosis
What kind of lesions does monensin toxicity cause in dogs?
Skeletal muscle necrosis
In which species would you need both heart and skeletal muscle for monensin toxicity diagnosis?
- Equine
2. Bovine
In which species would you only need skeletal muscle for monensin toxicity diagnosis?
- Sheep
- Swine
- Dog
What is the antidote for monensin?
None
