Introduction to Pathology Flashcards

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1
Q

what is pathology?

A

the study of the causes and effects of diseases

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2
Q

what does aetiology mean?

A

the cause, set of causes, or manner of causation of a disease or condition

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3
Q

what does pathogenesis mean?

A

progressive changes as disease develops

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4
Q

what does sequalae mean?

A

what happens next

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5
Q

how is anaemia related to the oral cavity?

A

burning red tongue, inflammation of gum tissues

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6
Q

how is diabetes related to the oral cavity?

A

dry mouth, bad breath, burning tongue, inflammation and tooth decay

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7
Q

how is anorexia nervosa and bulimia related to the oral cavity?

A

erosion of tooth enamel, fillings raised above eroded surface, sensitive teeth, enlargement of the parotid glands and sweet breath aroma

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8
Q

how is kidney failure related to the oral cavity?

A

retarded tooth development in children, dry mouth, odour, metallic taste and ulcers on the tongue and gums

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9
Q

how is HIV related to the oral cavity?

A

sores, thrush, non-removable white areas on the side of the tongue

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10
Q

how is heart disease related to the oral cavity?

A

pain radiating to the jaw caused by insufficient oxygen to the heart muscle

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11
Q

what does the lymphatic system do?

A

transport clean fluids back to the blood, drains excess fluids from tissues, removes debris from cells of body transports fats from digestive system

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12
Q

what is the difference between innate and adaptive immunity?

A

innate immunity is the first line of defence whilst adaptive immunity is specific and acquired

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13
Q

what are the three main parts of innate immunity?

A

epithelium, innate cell subsets and complement, chemokines and cytokines

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14
Q

what does epithelium do in innate immunity?

A

it is a physical barrier, produces antimicrobial peptides and cytokines/chemokines

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15
Q

what are the innate cell subsets in innate immunity?

A

phagocytic cells (macrophages, neutrophils) and antigen-presenting cells (dendritic cells)

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16
Q

what do chemokines do?

A

cell recruitment

17
Q

what do cytokines do?

A

cell activation/proliferation

18
Q

what cells are involved in adaptive immunity?

A

B cells and T cells

19
Q

what do B cells do?

A

produce antibodies

20
Q

what do T cells do?

A

cell-cell communication

21
Q

describe innate immunity?

A

regular contact with potential pathogens which are destroyed within minutes or hours, only rarely causing disease

22
Q

when does innate immunity take place in the immune response?

A

1-3 days

23
Q

describe adaptive immunity?

A

repeat infections met immediately with strong and specific response

24
Q

when does adaptive immunity take place in immune response?

A

4-10 days

25
Q

what does inflammatory reaction aim to eliminate?

A

invading microorganisms, particulate materials, altered self cells and transformed malignant cells

26
Q

what are the 5 stages of inflammation?

A

initiation - progression - amplification - resolution - failure to resolve

27
Q

what is initiation?

A

response to harmful agents

28
Q

what is progression?

A

containment of harmful agents

29
Q

what is amplification?

A

modulation of immune responses

30
Q

what is resolution?

A

healing (for acute inflammation)

31
Q

what happens if inflammation fails to resolve?

A

it progresses to chronic inflammation

32
Q

what is acute inflammation?

A

appropriate response for threat, resolution when no longer required

33
Q

what is chronic resolution?

A

unresolved, failures in control mechanisms, self-damage

34
Q

what can inappropriate immune response cause?

A

pathologies