Intro Flashcards
1
Q
3 Approaches to Pharmacology
A
Mechanistic - control tissue/cell
Drug - find functions knowing drug action
Disease - control particular disease
2
Q
Kd = (3)
A
k-1/k1 = C][R/CR = concentration at which 50% of sites are occupied
3
Q
Binding Equation (2)
A
B = BmaxC/(C + Kd) or B/Bmax = C/(C + Kd)
4
Q
Effect Equation (2)
A
E = EmaxC/(C + EC50) or E/Emax = C/(C + E50)
5
Q
2 Types of Antagonists in Terms of Emax and EC50
A
Competitive: Emax unchanged, increased EC50
Noncompetitive: Decreased Emax, unchanged EC50
6
Q
Therapeutic Index
A
TD50/ED50 - larger is better
