Drug Pass, Metabolism, and Elimination Flashcards
1
Q
Eq to Calculate Constant Infusion
A
Q = 0.7x/t1/2
2
Q
Clearance Equation
A
CL = 0.7Vd/t1/2
3
Q
3 Important Clearance Rates
A
Renal Plasma Flow: 750 mL/min (actively secreted)
GFR: 120 ml/min (lipid insoluble)
Urine Flow Rate: 1-2 ml/min (lipid soluble)
4
Q
Dosing Rate Eq
A
Clearance x Target Conc
5
Q
Maintenance Dose Eq
A
(Dosing Rate/Bioavaibility) x Dosing Interval
6
Q
2 Important Enzymes of CYP Complex
A
CYP Oxidase and Reductase
7
Q
Goal of Phase I
A
Functionalization
8
Q
Goal of Phase II
A
Conjugation
9
Q
3 Body Water Volumes
A
Blood = 2.8L
EC Water = 14L
Total Water = 42L
