Antibiotics Flashcards
1
Q
Macrolides (2 examples, use, mech)
A
Azithro/erythromycin
Pulmonary Infections
Bind reversibly to 50S to block protein translation
2
Q
Example of Synergy
A
Penicillin weakens cell wall allowing efficient uptake of aminoglycosides
3
Q
4 Mechs of Action
A
Cell Wall, Protein, or NA synth inhibition
Alteration of cell membrane function
4
Q
MBC
A
Minimal Bactericidal Concentration, that required to reduces # of viable bacteria 1000 fold
5
Q
Attainable Level of Antibiotic
A
Conc that can be reached in target tissue w/out toxic side effects, must be greater than MIC for 90% of isolates for susceptibility
6
Q
2 Mitigating Factors on Troughs
A
Post Antibiotic Effect
Synergism b/w host defenses and low antibiotic levels
